Faden A, Jacobs T, Woods M
Brain Res. 1979 Feb 16;162(1):13-20. doi: 10.1016/0006-8993(79)90751-0.
Electrical stimulation of the zona intermedia of the lower thoracic/upper lumbar cat spinal cord resulted in increases of heart rate (HR), blood pressure (BP) and cardiac contractility (dp/dt). Sites of maximal cardiovascular response (SMCR) were localized histologically to the intermediolateral nucleus (ILN). The inotropic and chronotropic responses were abolished by spinal cord transection or hemisection two to three segments rostral to the site of stimulation. Discrete electrolytic lesions in the white matter adjacent to the ILN were also shown to markedly decrease or abolish the chronotropic and inotropic responses elicited by stimulation of a more caudal SMCR. Longitudinal spinal section resulted in decreased cardiovascular responses from an SMCR; these changes were larger on the left side and greatest for BP as compared to HR and dp/dt. These findings indicate the existence of an ascending intraspinal cardiovascular pathway located in the deep white matter adjacent to the ILN. They further suggest that this is the intraspinal sympathetic preganglionic pathway recently described anatomically.
对猫胸段下部/腰段上部脊髓中间带进行电刺激，可导致心率（HR）、血压（BP）和心脏收缩力（dp/dt）增加。最大心血管反应部位（SMCR）经组织学定位至中间外侧核（ILN）。脊髓在刺激部位头端两到三个节段处横断或半横断后，变力性和变时性反应消失。与ILN相邻白质中的离散电解损伤也显示，可显著降低或消除由更尾端的SMCR刺激所引发的变时性和变力性反应。脊髓纵切导致来自SMCR的心血管反应降低；与HR和dp/dt相比，这些变化在左侧更大，对BP的影响最大。这些发现表明，在与ILN相邻的深部白质中存在一条脊髓内心血管上行通路。它们进一步表明，这就是最近在解剖学上描述的脊髓内交感神经节前通路。
