Yoshimoto Y
Department of Otolaryngology, Teikyo University School of Medicine, Tokyo, Japan.
Acta Otolaryngol Suppl. 1995;519:114-7. doi: 10.3109/00016489509121883.
Harada's disease is an uncommon autoimmune disease affecting melanocytes located in the uvea, inner ear, skin, hair, and meninges. A classification of Harada's disease presenting with aural symptoms, especially vertigo, was devised on the basis of otoneurological findings. Peripheral vestibular dysfunction, such as staggering in the stepping test, rotato-horizontal or horizontal nystagmus, and diminished labyrinthine function in the caloric nystagmus test, was observed in the vast majority of these patients. Harada's disease with such features was designated as the peripheral type, and was further divided into vestibular, cochleo-vestibular, and cochlear subtypes. Patients only rarely presented with symptoms or signs of central nervous system involvement, and Harada's disease with such features was designated as the central type.
原田病是一种罕见的自身免疫性疾病，会影响位于葡萄膜、内耳、皮肤、毛发和脑膜的黑素细胞。基于耳神经学检查结果，制定了一种伴有耳部症状（尤其是眩晕）的原田病分类方法。在这些患者中，绝大多数都观察到了外周前庭功能障碍，如步行试验时蹒跚、旋转性水平或水平性眼球震颤，以及冷热试验中迷路功能减退。具有这些特征的原田病被指定为外周型，并进一步分为前庭型、耳蜗-前庭型和耳蜗型亚型。仅有少数患者出现中枢神经系统受累的症状或体征，具有这些特征的原田病被指定为中枢型。
