Levitt P, Moore R Y
Brain Res. 1979 Feb 23;162(2):243-59. doi: 10.1016/0006-8993(79)90287-7.
The development of the noradrenaline (NA)-neuron innervation of rat neocortex was studied by fluorescence histochemistry, high affinity uptake of [3H-]NA, and biochemical assay of regional NA content. Fluorescence histochemistry indicates that NA axons enter areas of developing neocortex prenatally and the innervation matures rapidly during early postnatal life. Frontal and lateral neocortical areas are the first to be innervated followed by occipital and parietal areas. All cortical layers receive innervation. The distribution and density of neocortical NA innervation achieves the adult pattern by the end of the first postnatal week. High affinity uptake studies confirm the observations from fluorescence histochemistry and show a very rapid maturation of the NA axon innervation with adult levels of uptake occurring by postnatal day 9. Following birth, there is a brief rise in NA content from PO to P2 in all neocortical areas. NA content then drops to low levels in all areas by P4. This is followed by a gradual increase in NA content in all areas occuring over several months. This pattern of development of NA axon innervation of neocortex demonstrates that the density and distribution of NA axons in developing neocortex matures much earlier than shown in previous studies whereas the NA content of the developing axonal plexus achieves adult levels later in postnatal life.
通过荧光组织化学、[3H-]去甲肾上腺素（NA）的高亲和力摄取以及区域NA含量的生化测定，研究了大鼠新皮质中去甲肾上腺素（NA）神经元的神经支配发育情况。荧光组织化学表明，NA轴突在产前进入发育中的新皮质区域，且在出生后早期神经支配迅速成熟。额叶和外侧新皮质区域首先受到神经支配，随后是枕叶和顶叶区域。所有皮质层均接受神经支配。出生后第一周结束时，新皮质NA神经支配的分布和密度达到成年模式。高亲和力摄取研究证实了荧光组织化学的观察结果，并显示NA轴突神经支配迅速成熟，在出生后第9天达到成年摄取水平。出生后，所有新皮质区域的NA含量从出生后0天（P0）到第2天（P2）有短暂升高。然后，到出生后第4天（P4），所有区域的NA含量降至低水平。随后，所有区域的NA含量在几个月内逐渐增加。新皮质NA轴突神经支配的这种发育模式表明，发育中的新皮质中NA轴突的密度和分布比以前的研究显示的成熟得更早，而发育中的轴突丛的NA含量在出生后较晚达到成年水平。
