Fassina G
TECNOGEN S.C.p.A., Piana di Monte Verna, (CE), Italy.
Agents Actions Suppl. 1995;46:109-20. doi: 10.1007/978-3-0348-7276-8_11.
The possibility of designing sequence-directed recognition peptides (complementary peptides) able to non covalently associate target peptides or proteins is one of the most important applications deriving from the Molecular Recognition Theory [MRT]. Complementary peptides can be used widely not only as synthetic ligands for the development of affinity purification strategies to isolate target peptides or proteins from crude sources, but more importantly as peptidyl antagonists to inhibit biologically relevant interactions, or to probe functional sites in proteins and corresponding receptors.
设计能够与靶肽或蛋白质非共价结合的序列导向识别肽（互补肽）的可能性，是分子识别理论（MRT）衍生出的最重要应用之一。互补肽不仅可广泛用作合成配体，用于开发亲和纯化策略，从粗提物中分离靶肽或蛋白质，更重要的是可作为肽基拮抗剂，抑制生物学相关的相互作用，或探测蛋白质及相应受体中的功能位点。
