近年来对胞质型磷脂酶A2的结构、功能及生物学特性的深入了解。
Recent insights into the structure, function and biology of cPLA2.
作者信息
Kramer R M, Sharp J D
机构信息
Lilly Research Laboratories, Indianapolis, Indiana 46285, USA.
出版信息
Agents Actions Suppl. 1995;46:65-76. doi: 10.1007/978-3-0348-7276-8_7.
The 85-kDa cytosolic PLA2 (cPLA2) is present in most cells and tissues and its structural and functional properties have been described. Different agonists, growth factors and cytokines activate cPLA2 to hydrolyze cellular phospholipids thereby providing the precursor substrates for the biosynthesis of eicosanoids and platelet-activating factor (PAF), the well-known mediators of inflammatory and allergic reactions. Recent studies discussed here suggest that cPLA2 is a receptor-regulated enzyme involved in the inflammatory response. Therefore, inhibitors of cPLA2 may be useful as therapeutic agents in the treatment of inflammatory diseases.
85千道尔顿的胞质磷脂酶A2（cPLA2）存在于大多数细胞和组织中，其结构和功能特性已被描述。不同的激动剂、生长因子和细胞因子激活cPLA2以水解细胞磷脂，从而为类花生酸和血小板活化因子（PAF）的生物合成提供前体底物，PAF是炎症和过敏反应的著名介质。本文讨论的最新研究表明，cPLA2是一种参与炎症反应的受体调节酶。因此，cPLA2抑制剂可能作为治疗炎症性疾病的治疗药物。
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