免疫化学粪便潜血试验对结直肠肿瘤的敏感性评估。

Evaluation of the sensitivity of an immunochemical fecal occult blood test for colorectal neoplasia.

作者信息

Yoshinaga M, Motomura S, Takeda H, Yanagisawa Z, Ikeda K

机构信息

Department of Internal Medicine and Surgery, Fukuoka Teishin Hospital, Japan.

出版信息

Am J Gastroenterol. 1995 Jul;90(7):1076-9.

PMID:7611200

Abstract

OBJECTIVES

This study was designed to evaluate the sensitivity of OC-Hemodia, a immunochemical fecal occult blood test (IFOBT) based on the technique of latex agglutination for early stage colorectal cancer and clinically significant adenomas.

METHODS

The study was conducted on 885 patients who underwent OC-Hemodia and a colonoscopy.

RESULTS

Colorectal cancers were detected in 23 patients (10 Dukes' A, eight Dukes' B, and five Dukes' C or D). Adenomas were detected in 459 patients (16 villous adenomas 433 tubular adenomas with mild or moderate dysplasia, and 10 with severe dysplasia). The sensitivity of OC-Hemodia was 90% for those with Dukes' A colon cancer and 100% for those with Dukes' B, C, or D colon cancer. It was 18.8% for those with villous changes, and 40% for those with severe dysplasia.

CONCLUSIONS

These results suggest that the IFOBT is not a reliable test for the screening of premalignant adenomas, although it is useful for detecting early stage colorectal cancers.

摘要

目的

本研究旨在评估OC-Hemodia的敏感性，OC-Hemodia是一种基于乳胶凝集技术的免疫化学粪便潜血试验（IFOBT），用于早期结直肠癌和具有临床意义的腺瘤。

方法

对885例行OC-Hemodia检查和结肠镜检查的患者进行了研究。

结果

23例患者检测到结直肠癌（10例杜克A期、8例杜克B期、5例杜克C期或D期）。459例患者检测到腺瘤（16例绒毛状腺瘤、433例轻度或中度发育异常的管状腺瘤、10例重度发育异常的管状腺瘤）。OC-Hemodia对杜克A期结肠癌患者的敏感性为90%，对杜克B期、C期或D期结肠癌患者的敏感性为100%。对有绒毛状改变的患者敏感性为18.8%，对有重度发育异常的患者敏感性为40%。