Kuppens E V, van Best J A, Sterk C C, de Keizer R J
Department of Ophthalmology, Leiden University Hospital, The Netherlands.
Am J Ophthalmol. 1995 Jul;120(1):41-6. doi: 10.1016/s0002-9394(14)73757-2.
To detect whether untreated primary open-angle glaucoma or ocular hypertension is associated with an impaired basal tear turnover.
Basal tear turnover was determined by fluorophotometry in 18 patients with newly detected, untreated primary open-angle glaucoma and 29 patients with untreated ocular hypertension. The results were compared with those of 27 age-matched control subjects.
The basal tear turnover in glaucoma patients (mean +/- S.D., 11.4 +/- 3.1%/min) was 22% lower than in patients with ocular hypertension (14.7 +/- 3.0%/min; P = .0007) and 27% lower than in control subjects (15.7 +/- 5.3%/min; P = .001). Tear turnover of patients with ocular hypertension did not differ significantly from that of control subjects (P = .4). The basal tear turnover values were found to decrease with increasing vertical or horizontal cup/disk ratios (P = .004 and P = .008, respectively).
Primary open-angle glaucoma, but not ocular hypertension, was found to be associated with an impaired basal tear turnover. Dry eye complaints may originate from decreased basal tear turnover as a result of glaucoma drug therapy as well as from primary open-angle glaucoma itself.
检测未经治疗的原发性开角型青光眼或高眼压症是否与基础泪液更新受损有关。
通过荧光光度法测定18例新诊断的未经治疗的原发性开角型青光眼患者和29例未经治疗的高眼压症患者的基础泪液更新情况。将结果与27例年龄匹配的对照者进行比较。
青光眼患者的基础泪液更新率（均值±标准差，11.4±3.1%/分钟）比高眼压症患者（14.7±3.0%/分钟；P = 0.0007）低22%，比对照者（15.7±5.3%/分钟；P = 0.001）低27%。高眼压症患者的泪液更新率与对照者相比无显著差异（P = 0.4）。发现基础泪液更新值随垂直或水平杯盘比的增加而降低（分别为P = 0.004和P = 0.008）。
发现原发性开角型青光眼而非高眼压症与基础泪液更新受损有关。干眼症状可能源于青光眼药物治疗导致的基础泪液更新减少以及原发性开角型青光眼本身。
