肝脏α1B - 肾上腺素能受体和β2 - 肾上腺素能受体的反向调节。细胞机制及生理意义。 - Suppr

Inverse regulation of hepatic alpha 1B- and beta 2-adrenergic receptors. Cellular mechanisms and physiological implications.

作者信息

Kunos G, Ishac E J, Gao B, Jiang L

机构信息

Department of Pharmacology & Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA.

出版信息

Ann N Y Acad Sci. 1995 May 10;757:261-71. doi: 10.1111/j.1749-6632.1995.tb17483.x.

DOI:10.1111/j.1749-6632.1995.tb17483.x

PMID:7611682

Abstract

摘要

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Inverse regulation of hepatic alpha 1B- and beta 2-adrenergic receptors. Cellular mechanisms and physiological implications.肝脏α1B - 肾上腺素能受体和β2 - 肾上腺素能受体的反向调节。细胞机制及生理意义。

Ann N Y Acad Sci. 1995 May 10;757:261-71. doi: 10.1111/j.1749-6632.1995.tb17483.x.

Time dependent conversion from alpha 1- to beta-adrenoceptor-mediated glycogenolysis in isolated rat hepatocytes: role of membrane phospholipase A2 and protein kinase C.离体大鼠肝细胞中α1-肾上腺素能受体介导的糖原分解向β-肾上腺素能受体介导的糖原分解的时间依赖性转变：膜磷脂酶A2和蛋白激酶C的作用

Clin Exp Pharmacol Physiol. 1987 May;14(5):429-35. doi: 10.1111/j.1440-1681.1987.tb00994.x.

Adrenergic receptors: possible mechanism of inverse regulation of alpha- and beta-receptors.肾上腺素能受体：α和β受体反向调节的可能机制

J Allergy Clin Immunol. 1985 Aug;76(2 Pt 2):346-51. doi: 10.1016/0091-6749(85)90652-9.

Mechanism of inverse regulation of alpha 1- and beta-adrenergic receptors.

Biochem Pharmacol. 1987 Apr 15;36(8):1185-91. doi: 10.1016/0006-2952(87)90068-2.

Avenues of adrenergic research.

J Lab Clin Med. 1979 Sep;94(3):381-6.

Time-dependent conversion of alpha 1- to beta-adrenoceptor-mediated glycogenolysis in isolated rat liver cells: role of membrane phospholipase A2.离体大鼠肝细胞中α1-肾上腺素能受体介导的糖原分解向β-肾上腺素能受体介导的糖原分解的时间依赖性转变：膜磷脂酶A2的作用

Proc Natl Acad Sci U S A. 1984 Oct;81(19):6178-82. doi: 10.1073/pnas.81.19.6178.

Noradrenergic modulation of albumin expression in growth-stimulated adult rat hepatocytes in primary culture.原代培养的生长刺激成年大鼠肝细胞中白蛋白表达的去甲肾上腺素能调节。

J Cell Physiol. 1994 Mar;158(3):513-7. doi: 10.1002/jcp.1041580316.

Phorbol esters inhibit alpha 1 adrenergic stimulation of glycogenolysis in isolated rat hepatocytes.佛波酯抑制离体大鼠肝细胞中α1肾上腺素能对糖原分解的刺激作用。

Biochem Biophys Res Commun. 1984 Mar 30;119(3):1128-33. doi: 10.1016/0006-291x(84)90892-1.

Steady state levels of hepatic alpha 1- and beta 2-adrenergic receptors and gene transcripts during development of the male rat.雄性大鼠发育过程中肝脏α1和β2肾上腺素能受体及基因转录本的稳态水平

J Cell Physiol. 1991 Apr;147(1):55-61. doi: 10.1002/jcp.1041470108.

Transcriptional activation of the cardiac myosin light chain 2 and atrial natriuretic factor genes by protein kinase C in neonatal rat ventricular myocytes.蛋白激酶C对新生大鼠心室肌细胞中心肌肌球蛋白轻链2和心钠素基因的转录激活作用。

Proc Natl Acad Sci U S A. 1992 Feb 15;89(4):1305-9. doi: 10.1073/pnas.89.4.1305.

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Sleep-disordered breathing in pregnancy: a developmental origin of offspring obesity?妊娠睡眠障碍性呼吸：后代肥胖的发育起源？

J Dev Orig Health Dis. 2021 Apr;12(2):237-249. doi: 10.1017/S2040174420000355. Epub 2020 May 19.

Clinicopathological significances of Feline sarcoma-related protein and β2-adrenoceptor expression in pancreatic ductal adenocarcinomas.猫肉瘤相关蛋白和β2-肾上腺素能受体在胰腺导管腺癌中的表达的临床病理意义

Int J Clin Exp Pathol. 2019 Sep 1;12(9):3390-3398. eCollection 2019.

The eukaryotic translation initiation factor 3f (eIF3f) interacts physically with the alpha 1B-adrenergic receptor and stimulates adrenoceptor activity.真核生物翻译起始因子3f（eIF3f）与α1B - 肾上腺素能受体发生物理相互作用，并刺激肾上腺素能受体活性。

BMC Biochem. 2015 Oct 23;16:25. doi: 10.1186/s12858-015-0054-5.

Alpha1-and beta2-adrenoceptors in the human liver with mass-forming intrahepatic cholangiocarcinoma: density and coupling to adenylate cyclase and phospholipase C.人肝脏中伴有肿块形成的肝内胆管癌的α1和β2肾上腺素能受体：密度及其与腺苷酸环化酶和磷脂酶C的偶联

Naunyn Schmiedebergs Arch Pharmacol. 2005 Nov;372(3):171-81. doi: 10.1007/s00210-005-0017-2. Epub 2005 Nov 15.

The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic.丝裂原活化蛋白（MAP）激酶级联反应在大鼠肝细胞原代培养中，根据其激活是急性/阶段性的还是慢性的，既可以刺激也可以抑制DNA合成。

Biochem J. 1998 Mar 15;330 ( Pt 3)(Pt 3):1451-60. doi: 10.1042/bj3301451.

The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes.Ras/Rac1/Cdc42/SEK/JNK/c-Jun信号级联反应是激动剂刺激大鼠原代肝细胞培养物中DNA合成的关键途径。

Mol Biol Cell. 1998 Mar;9(3):561-73. doi: 10.1091/mbc.9.3.561.

Differential regulation of the mitogen-activated protein and stress-activated protein kinase cascades by adrenergic agonists in quiescent and regenerating adult rat hepatocytes.肾上腺素能激动剂对成年大鼠静止期和再生期肝细胞有丝分裂原激活蛋白激酶及应激激活蛋白激酶级联反应的差异调节

Mol Cell Biol. 1997 Jul;17(7):3556-65. doi: 10.1128/MCB.17.7.3556.

Tissue-specific modulation of insulin receptor mRNA levels in adrenaline-treated rats.肾上腺素处理大鼠中胰岛素受体mRNA水平的组织特异性调节

Mol Cell Biochem. 1997 Apr;169(1-2):165-9. doi: 10.1023/a:1006872309179.

Transcriptional regulation of alpha(1b) adrenergic receptors (alpha(1b)AR) by nuclear factor 1 (NF1): a decline in the concentration of NF1 correlates with the downregulation of alpha(1b)AR gene expression in regenerating liver.核因子1（NF1）对α1b肾上腺素能受体（α1bAR）的转录调控：在再生肝脏中，NF1浓度的下降与α1bAR基因表达的下调相关。

Mol Cell Biol. 1996 Nov;16(11):5997-6008. doi: 10.1128/MCB.16.11.5997.

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Inverse regulation of hepatic alpha 1B- and beta 2-adrenergic receptors. Cellular mechanisms and physiological implications.

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