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Basis for natural variation in sensitivity to 5-fluorouracil in mouse and human cells in culture.

作者信息

Laskin J D, Evans R M, Slocum H K, Burke D, Hakala M T

出版信息

Cancer Res. 1979 Feb;39(2 Pt 1):383-90.

PMID:761209
Abstract
摘要

相似文献

1
Basis for natural variation in sensitivity to 5-fluorouracil in mouse and human cells in culture.培养的小鼠和人类细胞对5-氟尿嘧啶敏感性自然变异的基础。
Cancer Res. 1979 Feb;39(2 Pt 1):383-90.
2
Effects of sodium warfarin and other carcinostatic agents on malignant cells: a study of drug synergy.华法林钠及其他抗癌剂对恶性细胞的作用：药物协同作用研究
J Med. 1974;5(1):69-82.
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Assessment of growth-limiting events caused by 5-fluorouracil in mouse cells and in human cells.对5-氟尿嘧啶在小鼠细胞和人类细胞中引起的生长限制事件的评估。
Cancer Res. 1980 Nov;40(11):4113-22.
4
Potentiation of the antitumor effect of 5-fluorouracil by some nucleotides, and their possible role in the potentiation.某些核苷酸对5-氟尿嘧啶抗肿瘤作用的增强及其在增强作用中可能的作用。
Jpn J Exp Med. 1983 Jun;53(3):155-63.
5
Studies on mechanisms of 5-fluorouracil resistance in murine and human tumors.关于小鼠和人类肿瘤中5-氟尿嘧啶耐药机制的研究。
Bull Cancer. 1979;66(1):55-9.
6
Characterization of a cisplatin-resistant human ovarian carcinoma cell line expressing cross-resistance to 5-fluorouracil but collateral sensitivity to methotrexate.一种对顺铂耐药的人卵巢癌细胞系的特征，该细胞系对5-氟尿嘧啶表现出交叉耐药性，但对甲氨蝶呤具有旁侧敏感性。
Cancer Res. 1992 Jun 1;52(11):3110-8.
7
[Characterization of a fluorouracil-resistant human gastric carcinoma cell line and its morphological behavior].
Zhongguo Yao Li Xue Bao. 1993 Nov;14 Suppl:S1-4.
8
Isolation of a cellular subpopulation from a human colonic carcinoma cell line.从人结肠癌细胞系中分离细胞亚群。
Cancer Res. 1980 May;40(5):1574-9.
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Effects of thymidine and thymidine plus 5-fluorouracil on the growth kinetics of a human lymphoid cell line.
Cancer Res. 1980 May;40(5):1543-9.
10
[Potentiation of the antitumor activity of 5-fluorouracil by biochemical modulators].[生化调节剂对5-氟尿嘧啶抗肿瘤活性的增强作用]
Gan To Kagaku Ryoho. 1988 Mar;15(3):380-91.

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Molecular Mechanisms and Tumor Biological Aspects of 5-Fluorouracil Resistance in HCT116 Human Colorectal Cancer Cells.HCT116人结肠癌细胞中5-氟尿嘧啶耐药的分子机制及肿瘤生物学方面
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Impact of 5-fluorouracil metabolizing enzymes on chemotherapy in patients with resectable colorectal cancer.
5-氟尿嘧啶代谢酶对可切除结直肠癌患者化疗的影响。
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Selection of suitable prodrug candidates for in vivo studies via in vitro studies; the correlation of prodrug stability in between cell culture homogenates and human tissue homogenates.通过体外研究选择适合体内研究的前药候选物；细胞培养匀浆和人体组织匀浆中前药稳定性的相关性。
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The feasibility of enzyme targeted activation for amino acid/dipeptide monoester prodrugs of floxuridine; cathepsin D as a potential targeted enzyme.酶靶向激活氟尿苷氨基酸/二肽单酯前药的可行性；组织蛋白酶 D 作为一种潜在的靶向酶。
Molecules. 2012 Mar 26;17(4):3672-89. doi: 10.3390/molecules17043672.
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Potential of amino acid/dipeptide monoester prodrugs of floxuridine in facilitating enhanced delivery of active drug to interior sites of tumors: a two-tier monolayer in vitro study.氟尿苷氨基酸/二肽单酯前药提高活性药物向肿瘤内部传递的潜力：双层单层体外研究。
Pharm Res. 2011 Oct;28(10):2575-88. doi: 10.1007/s11095-011-0485-7. Epub 2011 Jun 14.
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The achievement of mass balance by simultaneous quantification of floxuridine prodrug, floxuridine, 5-fluorouracil, 5-dihydrouracil, α-fluoro-β-ureidopropionate, α-fluoro-β-alanine using LC-MS.采用 LC-MS 同时定量检测氟尿苷前药、氟尿嘧啶、5-氟尿嘧啶、5-二氢尿嘧啶、α-氟-β-脲基丙酸、α-氟-β-丙氨酸，实现质量平衡。
J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Apr 15;879(13-14):915-20. doi: 10.1016/j.jchromb.2011.02.045. Epub 2011 Mar 5.
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L-type amino acid transporter 1 inhibitors inhibit tumor cell growth.L 型氨基酸转运蛋白 1 抑制剂抑制肿瘤细胞生长。
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Enhanced absorption and growth inhibition with amino acid monoester prodrugs of floxuridine by targeting hPEPT1 transporters.通过靶向hPEPT1转运蛋白，氟尿苷氨基酸单酯前药增强吸收并抑制生长。
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Enhanced cancer cell growth inhibition by dipeptide prodrugs of floxuridine: increased transporter affinity and metabolic stability.氟尿苷二肽前药增强癌细胞生长抑制作用：转运体亲和力和代谢稳定性增加。
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