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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Flora G J, Seth P K, Prakash A O, Mathur R

Industrial Toxicology Research Centre, Lucknow, India.

Hum Exp Toxicol. 1995 May;14(5):410-3. doi: 10.1177/096032719501400504.

The therapeutic ability of Ca disodium EDTA and meso 2,3-dimercaptosuccinic acid (DMSA) was studied, both individually and when given in combination, in reducing lead concentration in blood and other soft tissues, and in restoring lead induced altered biochemical variables in acute lead intoxicated rats. 2. Combined treatment with the above two chelating agents was more beneficial in reducing blood and hepatic lead compared to treatment with these drugs alone. Kidney lead concentration however, remained high following combined treatment, indicating the possibility of extra renal burden following treatment. 3. Lead sensitive biochemical variables also responded more favourably to combined treatment than treatment with these drugs alone. However, clinical biochemical indices indicate caution regarding the use of this new treatment regimen, and further investigation is required.

研究了依地酸钙钠和内消旋2,3-二巯基琥珀酸（DMSA）单独使用以及联合使用时，在降低急性铅中毒大鼠血液和其他软组织中铅浓度，以及恢复铅诱导的生化变量改变方面的治疗能力。2. 与单独使用这些药物治疗相比，上述两种螯合剂联合治疗在降低血液和肝脏铅含量方面更有益。然而，联合治疗后肾脏铅浓度仍然很高，表明治疗后可能存在肾外负担。3. 铅敏感的生化变量对联合治疗的反应也比对单独使用这些药物治疗的反应更有利。然而，临床生化指标表明在使用这种新治疗方案时需谨慎，还需要进一步研究。

Flora G J, Seth P K, Prakash A O, Mathur R

Industrial Toxicology Research Centre, Lucknow, India.

Hum Exp Toxicol. 1995 May;14(5):410-3. doi: 10.1177/096032719501400504.

The therapeutic ability of Ca disodium EDTA and meso 2,3-dimercaptosuccinic acid (DMSA) was studied, both individually and when given in combination, in reducing lead concentration in blood and other soft tissues, and in restoring lead induced altered biochemical variables in acute lead intoxicated rats. 2. Combined treatment with the above two chelating agents was more beneficial in reducing blood and hepatic lead compared to treatment with these drugs alone. Kidney lead concentration however, remained high following combined treatment, indicating the possibility of extra renal burden following treatment. 3. Lead sensitive biochemical variables also responded more favourably to combined treatment than treatment with these drugs alone. However, clinical biochemical indices indicate caution regarding the use of this new treatment regimen, and further investigation is required.

研究了依地酸钙钠和内消旋2,3-二巯基琥珀酸（DMSA）单独使用以及联合使用时，在降低急性铅中毒大鼠血液和其他软组织中铅浓度，以及恢复铅诱导的生化变量改变方面的治疗能力。2. 与单独使用这些药物治疗相比，上述两种螯合剂联合治疗在降低血液和肝脏铅含量方面更有益。然而，联合治疗后肾脏铅浓度仍然很高，表明治疗后可能存在肾外负担。3. 铅敏感的生化变量对联合治疗的反应也比对单独使用这些药物治疗的反应更有利。然而，临床生化指标表明在使用这种新治疗方案时需谨慎，还需要进一步研究。