Haskard D O
Department of Medicine (Rheumatology Unit), Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Curr Opin Rheumatol. 1995 May;7(3):229-34. doi: 10.1097/00002281-199505000-00012.
The adhesion mechanisms that enable leukocytes to migrate from the blood and function within inflamed synovium continue to occupy an area of intense investigation. Over the past year, advances have been made in understanding the specialized roles that individual adhesion molecules play in the interactions between leukocytes and vascular endothelial cells in inflammation in general. Several articles have described the expression of novel adhesion molecules in rheumatoid synovium, and a number of reports on the measurement of soluble adhesion molecules in blood and in synovial fluid have appeared, although it is too early to know whether this is clinically useful. Finally, inhibiting adhesion molecule function in vivo remains an attractive option for anti-inflammatory therapy.
使白细胞能够从血液中迁移并在炎症滑膜内发挥作用的黏附机制，仍然是一个深入研究的领域。在过去的一年里，对于一般炎症中单个黏附分子在白细胞与血管内皮细胞相互作用中所起的特殊作用，人们有了进一步的认识。几篇文章描述了类风湿滑膜中新型黏附分子的表达，并且出现了一些关于血液和滑液中可溶性黏附分子测量的报告，不过现在判断这是否具有临床实用性还为时过早。最后，在体内抑制黏附分子功能仍然是抗炎治疗的一个有吸引力的选择。
