• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
DNA minor groove binding of cross-linked lexitropsins: experimental conditions required to observe the covalently linked WPPW (groove wall-peptide-peptide-groove wall) motif.交联左旋曲菌素的DNA小沟结合：观察共价连接的WPPW（沟壁-肽-肽-沟壁）基序所需的实验条件。
Biophys J. 1995 May;68(5):2041-8. doi: 10.1016/S0006-3495(95)80382-6.
2
Progress in the design of DNA sequence-specific lexitropsins.DNA序列特异性左旋亲菌素设计的进展。
Biopolymers. 1997;44(4):323-34. doi: 10.1002/(SICI)1097-0282(1997)44:4<323::AID-BIP2>3.0.CO;2-0.
3
Antiparallel side-by-side dimeric motif for sequence-specific recognition in the minor groove of DNA by the designed peptide 1-methylimidazole-2-carboxamide netropsin.通过设计的肽1-甲基咪唑-2-甲酰胺纺锤菌素在DNA小沟中进行序列特异性识别的反平行并排二聚体基序。
Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7586-90. doi: 10.1073/pnas.89.16.7586.
4
Molecular recognition between oligopeptides and nucleic acids. Specificity of binding of a monocationic bis-furan lexitropsin to DNA deduced from footprinting and 1H NMR studies.寡肽与核酸之间的分子识别。通过足迹法和核磁共振氢谱研究推断单阳离子双呋喃类亲旋菌素与DNA结合的特异性。
J Mol Recognit. 1989 Sep;2(2):84-93. doi: 10.1002/jmr.300020206.
5
The binding of prototype lexitropsins to the minor groove of DNA: quantum chemical studies.原型嗜肝病毒蛋白与DNA小沟的结合：量子化学研究
J Biomol Struct Dyn. 1991 Oct;9(2):299-313. doi: 10.1080/07391102.1991.10507914.
6
Investigation of the Factors That Dictate the Preferred Orientation of Lexitropsins in the Minor Groove of DNA.研究决定 Lexitropsin 在 DNA 小沟中首选取向的因素。
J Med Chem. 2019 Nov 27;62(22):10423-10440. doi: 10.1021/acs.jmedchem.9b01534. Epub 2019 Nov 8.
7
Molecular recognition and binding of a GC site-avoiding thiazole-lexitropsin to the decadeoxyribonucleotide d-[CGCAATTGCG]2: 1H-NMR evidence for thiazole intercalation.一种避免GC位点的噻唑类lexitropsin与十脱氧核糖核苷酸d-[CGCAATTGCG]2的分子识别与结合：噻唑插入的1H-NMR证据
J Biomol Struct Dyn. 1990 Aug;8(1):99-121. doi: 10.1080/07391102.1990.10507792.
8
DNA recognition by lexitropsins, minor groove binding agents.
J Mol Recognit. 1994 Jun;7(2):79-88. doi: 10.1002/jmr.300070205.
9
Recent developments in sequence selective minor groove DNA effectors.序列选择性小沟DNA效应物的最新进展。
Curr Med Chem. 2001 Apr;8(5):475-508. doi: 10.2174/0929867003373292.
10
Influence of the methyl substituents of a thiazole-containing lexitropsin on the mode of binding to DNA.含噻唑的列克西曲菌素的甲基取代基对其与DNA结合模式的影响。
Anticancer Drug Des. 1995 Mar;10(2):155-66.

引用本文的文献

1
Design of stapled DNA-minor-groove-binding molecules with a mutable atom simulated annealing method.利用可变原子模拟退火方法设计钉状DNA小沟结合分子。
J Comput Aided Mol Des. 1997 Nov;11(6):539-46. doi: 10.1023/a:1007985019866.

本文引用的文献

1
Entropic contributions to rate accelerations in enzymic and intramolecular reactions and the chelate effect.熵对酶促反应和分子内反应速率加速的贡献以及螯合效应。
Proc Natl Acad Sci U S A. 1971 Aug;68(8):1678-83. doi: 10.1073/pnas.68.8.1678.
2
Mechanism of lysozyme action.溶菌酶的作用机制。
Science. 1969 Aug 1;165(3892):454-65. doi: 10.1126/science.165.3892.454.
3
Binding of an antitumor drug to DNA, Netropsin and C-G-C-G-A-A-T-T-BrC-G-C-G.一种抗肿瘤药物与DNA（Netropsin和C-G-C-G-A-A-T-T-BrC-G-C-G）的结合
J Mol Biol. 1985 Jun 25;183(4):553-63. doi: 10.1016/0022-2836(85)90171-8.
4
Lexitropsins: rational design of DNA sequence reading agents as novel anti-cancer agents and potential cellular probes.莱克西特罗辛：作为新型抗癌药物和潜在细胞探针的DNA序列读取剂的合理设计。
Anticancer Drug Des. 1988 Jun;3(1):25-40.
5
Structural characterization of a 2:1 distamycin A.d(CGCAAATTGGC) complex by two-dimensional NMR.通过二维核磁共振对2:1的双氢链霉素A.d（CGCAAATTGGC）复合物进行结构表征。
Proc Natl Acad Sci U S A. 1989 Aug;86(15):5723-7. doi: 10.1073/pnas.86.15.5723.
6
Nonintercalating DNA-binding ligands: specificity of the interaction and their use as tools in biophysical, biochemical and biological investigations of the genetic material.非嵌入型DNA结合配体：相互作用的特异性及其作为遗传物质生物物理、生化和生物学研究工具的应用
Prog Biophys Mol Biol. 1986;47(1):31-112. doi: 10.1016/0079-6107(86)90005-2.
7
Antiparallel side-by-side dimeric motif for sequence-specific recognition in the minor groove of DNA by the designed peptide 1-methylimidazole-2-carboxamide netropsin.通过设计的肽1-甲基咪唑-2-甲酰胺纺锤菌素在DNA小沟中进行序列特异性识别的反平行并排二聚体基序。
Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7586-90. doi: 10.1073/pnas.89.16.7586.
8
Lexitropsins in antiviral drug development.用于抗病毒药物研发的左西托辛类药物。
Antiviral Res. 1992 Mar;17(3):179-96. doi: 10.1016/0166-3542(92)90040-c.

交联左旋曲菌素的DNA小沟结合：观察共价连接的WPPW（沟壁-肽-肽-沟壁）基序所需的实验条件。

DNA minor groove binding of cross-linked lexitropsins: experimental conditions required to observe the covalently linked WPPW (groove wall-peptide-peptide-groove wall) motif.

作者信息

Chen Y H, Lown J W

机构信息

Department of Chemistry, University of Alberta, Edmonton, Canada.

出版信息

Biophys J. 1995 May;68(5):2041-8. doi: 10.1016/S0006-3495(95)80382-6.

DOI:10.1016/S0006-3495(95)80382-6
PMID:7612846
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1282107/
Abstract

A theoretical analysis of binding interactions between covalently cross-linked lexitropsins and DNA is undertaken, in which a novel cyclic symmetric 2:2 dimeric lexitropsin-DNA-binding model is proposed. Applicability of commonly used techniques including NMR, quantitative footprinting, CD, and ethidium fluorometry to differentiate the covalently linked WPPW (groove Wall-Peptide-Peptide-groove Wall) from a 2:2 cross-linked lexitropsin-DNA duplex structure is examined.

摘要

对共价交联的亲旋菌素与DNA之间的结合相互作用进行了理论分析，其中提出了一种新型的环状对称2:2二聚体亲旋菌素-DNA结合模型。研究了常用技术（包括核磁共振、定量足迹分析、圆二色光谱和溴化乙锭荧光测定法）区分共价连接的WPPW（沟壁-肽-肽-沟壁）与2:2交联的亲旋菌素-DNA双链体结构的适用性。