Woodward D E, Tyson R, Myerscough M R, Murray J D, Budrene E O, Berg H C
Department of Applied Mathematics, University of Washington, Seattle 98195, USA.
Biophys J. 1995 May;68(5):2181-9. doi: 10.1016/S0006-3495(95)80400-5.
We present experimental results on the bacterium Salmonella typhimurium which show that cells of chemotactic strains aggregate in response to gradients of amino acids, attractants that they themselves excrete. Depending on the conditions under which cells are cultured, they form periodic arrays of continuous or perforated rings, which arise sequentially within a spreading bacterial lawn. Based on these experiments, we develop a biologically realistic cell-chemotaxis model to describe the self-organization of bacteria. Numerical and analytical investigations of the model mechanism show how the two types of observed geometric patterns can be generated by the interaction of the cells with chemoattractant they produce.
我们展示了关于鼠伤寒沙门氏菌的实验结果，这些结果表明趋化性菌株的细胞会响应氨基酸梯度而聚集，氨基酸是它们自身分泌的引诱剂。根据细胞培养的条件，它们会形成连续或有孔环的周期性阵列，这些阵列在扩展的细菌菌苔中依次出现。基于这些实验，我们开发了一个生物学上逼真的细胞趋化模型来描述细菌的自组织。对模型机制的数值和分析研究表明，如何通过细胞与它们产生的化学引诱剂之间的相互作用产生两种观察到的几何图案。
