一种新型驱蚊剂（+）-优香茅醇的绝对构型及其差向异构体的驱蚊活性
Absolute configuration of a new mosquito repellent, (+)-eucamalol and the repellent activity of its epimer.
作者信息
Satoh A, Utamura H, Nakade T, Nishimura H
机构信息
Department of Bioscience and Technology, School of Engineering, Hokkaido Tokai University, Sapporo, Japan.
出版信息
Biosci Biotechnol Biochem. 1995 Jun;59(6):1139-41. doi: 10.1271/bbb.59.1139.
(+)-Eucamalol (1) and (-)-1-epi-eucamalol (2) were synthesized from (S)-(-)-perillaldehyde to determine the absolute configuration of 1, the structure of natural (+)-eucamalol being determined to be (1R,6R)-(+)-3-formyl-6-isopropyl-2-cyclohexen-1-ol. (+)-Eucamolol (1) and its 1-epimer (2) exhibited significant repellent activity against Aedes albopictus, and inhibited its feeding as well as DEET.
从（S）-（-）-紫苏醛合成了（+）-优香茅醇（1）和（-）-1-表优香茅醇（2），以确定1的绝对构型，天然（+）-优香茅醇的结构确定为（1R，6R）-（+）-3-甲酰基-6-异丙基-2-环己烯-1-醇。（+）-优香茅醇（1）及其1-差向异构体（2）对白纹伊蚊表现出显著的驱避活性，并抑制其取食，效果与避蚊胺相当。
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