Zdrenghea D, Angheloiu O, Icusca G, Timiş D
Division of Cardiology, Rehabilitation Hospital, Cluj-Napoca, Romania.
Rom J Intern Med. 1994 Oct-Dec;32(4):265-9.
A number of 21 patients with congestive heart failure (CHF) of various etiologies were studied. All patients were subjected to a classical exercise testing (ET) on cycloergometer. The ET was repeated 24 hrs later, 6 hrs after the administration of 2 mg Perindopril (Coversyl). No statistically significant differences in duration and intensity of ET before and after Perindopril were noted for the whole group. But in 9 patients (42.8%) at least one effort level was gained. In these patients the peak double product (DP) was similar before and after Perindopril, but at submaximal effort DP was, at each level, lesser after Perindopril, suggesting a mechanism of afterload reduction in the improvement of effort capacity.
对21例病因各异的充血性心力衰竭（CHF）患者进行了研究。所有患者均在蹬式测力计上进行了经典运动测试（ET）。24小时后重复进行ET，在服用2毫克培哚普利（雅施达）6小时后再次重复。整个组在服用培哚普利前后ET的持续时间和强度没有统计学上的显著差异。但在9例患者（42.8%）中至少提高了一个用力水平。在这些患者中，培哚普利前后的峰值双倍乘积（DP）相似，但在次最大用力时，培哚普利后每个水平的DP都较小，提示后负荷降低机制在用力能力改善中起作用。
