Gouvea V, Brantly M
Human Genetics Branch, National Institutes of Health, Bethesda, MD 20892, USA.
Trends Microbiol. 1995 Apr;3(4):159-62. doi: 10.1016/s0966-842x(00)88908-8.
Rotaviruses appear to exist as heterogeneous populations of reassortants and related variants. This phenomenon is consistent with the quasispecies concept of RNA viruses, and suggests that gene reassortment is a crucial evolutionary mechanism for this segmented virus. It also explains puzzling epidemiological findings and controversial results of vaccine-efficacy studies.