Schmidt R, Stippel D, Krings F, Pollok M
Department of Surgery, University of Cologne, Germany.
Br J Urol. 1995 May;75(5):572-7. doi: 10.1111/j.1464-410x.1995.tb07409.x.
To analyse the development of malignancies of the genito-urinary system after renal transplantation.
A total of 868 renal graft recipients were followed up over a mean period of 41.8 +/- 45 months. Fifteen patients received grafts from living related donors and 853 were transplanted with kidneys from cadavers.
Twelve patients (1.4%) exhibited cancer of the genito-urinary system: 11 tumours were de novo malignancies. One small renal carcinoma was transplanted from a living related donor. The incidence of tumours of the genito-urinary system was 34 in 100,000 patient years in the patients treated with cyclosporin and 32 in 100,000 patient years in the conventional therapy group. Four patients died within a mean survival time of 14.4 months. Comparison of our results with sex- and age-specific incidence rates in a reference population showed an increase in malignant tumours of the genitourinary system by a factor of 7.3 in males and 11.2 in females.
The frequency of disorders after transplantation necessitates routine examinations in organ transplanted recipients both before and at regular intervals after transplantation, including the patient's native kidneys and cervical smears in females.
分析肾移植后泌尿生殖系统恶性肿瘤的发生情况。
对868例肾移植受者进行了平均41.8±45个月的随访。15例患者接受了亲属活体供肾移植，853例接受了尸体肾移植。
12例患者（1.4%）出现泌尿生殖系统癌症：11例肿瘤为新发恶性肿瘤。1例小肾癌来自亲属活体供肾。环孢素治疗组泌尿生殖系统肿瘤的发病率为每10万患者年34例，传统治疗组为每10万患者年32例。4例患者在平均生存时间14.4个月内死亡。将我们的结果与参考人群中按性别和年龄划分的发病率进行比较，结果显示男性泌尿生殖系统恶性肿瘤发病率增加了7.3倍，女性增加了11.2倍。
移植后疾病的发生频率表明，器官移植受者在移植前和移植后定期进行常规检查很有必要，包括检查患者的原生肾脏以及女性的宫颈涂片。
