Paiva J F, Santos E A, Jeske W, Fareed J, Nader H B, Dietrich C P
Departamento de Bioquímica, Universidade Federal do Rio Grande do Norte, Natal, R.N., Brazil.
Comp Biochem Physiol A Physiol. 1995 Jul;111(3):495-9. doi: 10.1016/0300-9629(94)00021-k.
The anticlotting activities on some steps of the coagulation cascade of mollusc and mammalian heparins were studied. AT III-high affinity heparin is a more potent inhibitor than unfractionated heparin and mollusc heparin in the intrinsic and extrinsic pathways of thrombin and factor Xa generation. Mollusan heparin has about the same activity as the AT III high affinity-heparin on the inhibition of factor Xa and thrombin in the presence of antithrombin III and four times more inhibitory activity than unfractionated heparin on the heparin cofactor II mediated inhibition of thrombin.
研究了软体动物肝素和哺乳动物肝素在凝血级联反应某些步骤上的抗凝血活性。在凝血酶和因子Xa生成的内源性和外源性途径中，AT III高亲和力肝素比未分级肝素和软体动物肝素更具强效抑制作用。在抗凝血酶III存在的情况下，软体动物肝素在抑制因子Xa和凝血酶方面与AT III高亲和力肝素具有大致相同的活性，并且在肝素辅因子II介导的凝血酶抑制方面比未分级肝素具有四倍的抑制活性。
