Nordin U, Wannfors K, Colque-Navarro P, Möllby R, Heimdahl A
Department of Oral and Maxillofacial Surgery, Karolinska Institute, Huddinge, Sweden.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Apr;79(4):429-35. doi: 10.1016/s1079-2104(05)80122-2.
Patients with mandibular osteomyelitis had quantification of 10 antibodies against certain bacterial proteins and polysaccharides. Sera from 31 patients with acute or chronic osteomyelitis of the mandible and from 17 healthy controls were analyzed. Some patients showed low levels of investigated antibodies in general and a lack of specific antiteichoic acid antibodies, as well as of different antipneumococcal antibodies particularly. Two patients with therapy-resistant osteomyelitis showed IgG2 and IgG3 subclass deficiency. They had replacement therapy with intravenous 10 or 15 gm immunoglobulin every 3 weeks for 6 months. Both patients showed considerable improvement in their clinical symptoms after treatment with immunoglobulin. This study indicates that impaired humoral immune response may be of importance in subgroups of patients with osteomyelitis of the mandible.
患有下颌骨骨髓炎的患者对10种针对特定细菌蛋白和多糖的抗体进行了定量分析。分析了来自31名下颌骨急性或慢性骨髓炎患者以及17名健康对照者的血清。一些患者总体上所检测的抗体水平较低，缺乏特异性抗磷壁酸抗体，尤其是不同的抗肺炎球菌抗体。两名患有难治性骨髓炎的患者表现出IgG2和IgG3亚类缺乏。他们每3周接受一次静脉注射10或15克免疫球蛋白的替代疗法，持续6个月。两名患者在接受免疫球蛋白治疗后临床症状均有显著改善。这项研究表明，体液免疫反应受损在患有下颌骨骨髓炎的患者亚组中可能具有重要意义。
