Faggioni R, Benigni F, Ghezzi P
Laboratory of Neuroimmunology, Mario Negri Institute for Pharmacological Research, Milano, Italy.
Neuroimmunomodulation. 1995 Jan-Feb;2(1):2-15. doi: 10.1159/000096828.
Cytokines can be produced within the brain and are implicated as pathogenetic mediators of pathologies of the central nervous system (CNS). They cause various CNS effects, inducing fever, anorexia, sleepiness and activating the hypothalamus-pituitary-adrenal axis. Centrally administered cytokines cause peripheral effects such as induction of the synthesis of hepatic acute-phase proteins (APP). Some of their effects (e.g. anorexia, APP synthesis, fever) may result from both central and peripheral actions. Some represent feedback mechanisms that inhibit excess cytokine production.
细胞因子可在脑内产生，并被认为是中枢神经系统（CNS）疾病的发病介质。它们会引起多种中枢神经系统效应，导致发热、厌食、嗜睡，并激活下丘脑 - 垂体 - 肾上腺轴。中枢给予细胞因子会引起外周效应，如诱导肝脏急性期蛋白（APP）的合成。它们的一些效应（如厌食、APP合成、发热）可能是由中枢和外周作用共同导致的。有些则代表抑制细胞因子过度产生的反馈机制。
