Sugiyama T, Hashimoto K, Kiwamoto H, Ohnishi N, Esa A, Park Y C, Kurita T
Department of Urology, Kinki University School of Medicine, Osaka-Sayama, Japan.
Int J Urol. 1994 Dec;1(4):337-40. doi: 10.1111/j.1442-2042.1994.tb00060.x.
Twenty patients (1 male and 19 females) with senile dementia of the Alzheimer type were studied using cystometry in combination with sphincter electromyography, brain computed tomography (CT) and evaluating the activities of daily life (ADL), with special reference to urinary incontinence. Seven of the patients were continent and the remainder were incontinent. Cystometry revealed uninhibited detrusor contraction in 8 out of the 13 incontinent patients, while no uninhibited contraction was found in 7 continent patients. There was a significant correlation between uninhibited detrusor contraction and urinary incontinence (p < 0.05). Brain CT showed that the degree of brain atrophy was more severe in those with uninhibited contraction than those without (p < 0.05). There was no clear relationship between sphincter coordination and the occurrence of incontinence. The ADL score tended to be lower in incontinent patients, although no significant difference was apparent (0.05 < p < 0.1). Uninhibited detrusor contraction and poor ADL functioning caused by brain atrophy are thought to be major causes of urinary incontinence in patients with senile dementia of Alzheimer type.
对20例阿尔茨海默型老年痴呆患者（1例男性，19例女性）进行了研究，采用膀胱测压结合括约肌肌电图、脑部计算机断层扫描（CT）以及评估日常生活活动能力（ADL），特别关注尿失禁情况。其中7例患者无尿失禁，其余患者存在尿失禁。膀胱测压显示，13例尿失禁患者中有8例存在逼尿肌无抑制性收缩，而7例无尿失禁患者未发现无抑制性收缩。逼尿肌无抑制性收缩与尿失禁之间存在显著相关性（p<0.05）。脑部CT显示，存在无抑制性收缩的患者脑萎缩程度比无此情况的患者更严重（p<0.05）。括约肌协调性与尿失禁的发生之间没有明确关系。尿失禁患者的ADL评分往往较低，尽管差异不显著（0.05<p<0.1）。逼尿肌无抑制性收缩以及脑萎缩导致的ADL功能不佳被认为是阿尔茨海默型老年痴呆患者尿失禁的主要原因。
