小鼠输精管平滑肌中对河豚毒素敏感的动作电位。
Tetrodotoxin-sensitive action potentials in smooth muscle of mouse vas deferens.
作者信息
Holman M E, Tonta M A, Parkington H C, Coleman H A
机构信息
Department of Physiology, Monash University, Clayton, Victoria, Australia.
出版信息
J Auton Nerv Syst. 1995 Apr 8;52(2-3):237-40. doi: 10.1016/0165-1838(94)00157-f.
Action potentials were recorded during impalements of some but not all smooth muscle cells of mouse vas deferens in response to both nerve stimulation and intracellular current injection. They were resistant to blockade by nifedipine (0.1-1.0 microM) but were blocked by tetrodotoxin (TTX, 0.2-1.0 microM) when this was added in the presence of nifedipine. It is suggested that voltage-dependent sodium (Na+) channels are present in mouse vas deferens that function to amplify calcium (Ca2+) influx through voltage-dependent Ca2+ channels.
在对小鼠输精管部分而非全部平滑肌细胞进行刺入操作时，记录到了动作电位，这些动作电位是对神经刺激和细胞内电流注入的反应。它们对硝苯地平（0.1 - 1.0微摩尔）的阻断具有抗性，但当在硝苯地平存在的情况下加入河豚毒素（TTX，0.2 - 1.0微摩尔）时，动作电位被阻断。这表明小鼠输精管中存在电压依赖性钠（Na +）通道，其作用是放大通过电压依赖性钙（Ca2 +）通道的钙（Ca2 +）内流。
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