Harkey H L, al-Mefty O, Marawi I, Peeler D F, Haines D E, Alexander L F
Department of Neurosurgery, University of Mississippi Medical Center, Jackson, USA.
J Neurosurg. 1995 Aug;83(2):336-41. doi: 10.3171/jns.1995.83.2.0336.
Twelve dogs developed a delayed onset of neurological abnormalities from chronic cervical cord compression that was characteristic of myelopathy. The animals were divided into two groups and matched according to degree of neurological deficit. Six animals underwent decompression through removal of the anteriorly placed compressive device. Throughout the experiment, serial neurological examinations and somatosensory evoked potential studies were performed on each animal. Spinal cord blood flow measurements were obtained during each surgical procedure and at sacrifice. Magnetic resonance images were obtained after compression and before sacrifice. All animals in the decompressed group showed significant neurological improvement after decompression; no spontaneous improvement in neurological function was seen in the compressed group. On pathological examination, irreversible changes including large motor neuron loss, necrosis, and cavitation were seen in four of the animals in the decompressed group and five in the compressed group. Cervical spondylotic myelopathy in humans is known to respond to decompression; this study provides further evidence that this animal model for chronic compressive cervical myelopathy accurately reflects the disease process seen in humans.
12只狗因慢性颈髓压迫出现了延迟性神经功能异常，这是脊髓病的特征。这些动物被分为两组，并根据神经功能缺损程度进行匹配。6只动物通过移除前部放置的压迫装置进行减压。在整个实验过程中，对每只动物进行了系列神经学检查和体感诱发电位研究。在每次手术过程中和处死时测量脊髓血流量。在压迫后和处死前获取磁共振图像。减压组的所有动物在减压后神经功能均有显著改善；压迫组未观察到神经功能的自发改善。病理检查发现，减压组4只动物和压迫组5只动物出现了包括大运动神经元丧失、坏死和空洞形成在内的不可逆变化。已知人类的颈椎病性脊髓病对减压有反应；本研究进一步证明，这种慢性压迫性颈髓病的动物模型准确反映了人类所见的疾病过程。
