Kim C J
School of Pharmacy, Temple University, Philadelphia, PA 19140, USA.
J Pharm Sci. 1995 Mar;84(3):303-6. doi: 10.1002/jps.2600840308.
Drug release from compressed tablets manufactured with a powder mixture of poly(ethylene oxide) (PEO), a drug, and magnesium stearate is presented. Several factors such as molecular weight, drug loading, drug solubility, the pH of the dissolution medium, and stirring rate are investigated. The drug release from the high molecular weight PEO tablets (MW = 2 x 10(6) and 4 x 10(6)) is governed by the swelling of the polymer rather than by the erosion of the polymer, leading to anomalous release kinetics. However, the drug release from the low molecular weight PEO (MW = 0.9 x 10(6)) is controlled primarily by the swelling/erosion of the polymer, resulting in front synchronization and a constant release rate. It is observed that drug loading and drug solubility do not influence the release of drugs from low molecular weight PEO tablets. The pH of the dissolution medium and the stirring rate do not affect the drug release regardless of the molecular weight of the PEO.
介绍了由聚环氧乙烷（PEO）、一种药物和硬脂酸镁的粉末混合物制成的压制片中药物的释放情况。研究了诸如分子量、药物载量、药物溶解度、溶出介质的pH值和搅拌速率等几个因素。高分子量PEO片剂（MW = 2×10⁶和4×10⁶）中的药物释放受聚合物溶胀而非聚合物侵蚀的控制，导致异常释放动力学。然而，低分子量PEO（MW = 0.9×10⁶）中的药物释放主要受聚合物溶胀/侵蚀的控制，导致前沿同步和恒定释放速率。观察到药物载量和药物溶解度不影响低分子量PEO片剂中药物的释放。无论PEO的分子量如何，溶出介质的pH值和搅拌速率都不影响药物释放。
