Ni J W, Matsumoto K, Watanabe H
Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University, Japan.
Jpn J Pharmacol. 1995 Feb;67(2):137-41. doi: 10.1254/jjp.67.137.
Effects of tetramethylpyrazine (TMP), a major constituent of Ligusticum chuanxiong, on spatial cognitive impairment induced by permanent occlusion of bilateral common carotid arteries (2VO) and scopolamine were investigated using 8-arm radial maze performance in rats. Permanent 2VO produced a severe learning deficit in non-pretrained rats. Daily administration of TMP (3-10 mg/kg, i.p.) from the 3rd day after permanent 2VO significantly improved the learning deficit. TMP did not influence the impairment of the retention task in the pretrained permanent 2VO rats, but it tended to reduce the number of errors elevated by 3-min delay interposition in these rats. In the scopolamine model, scopolamine (0.3 mg/kg, i.p.) significantly decreased the initial correct response and increased the number of errors. Single administration of TMP (1-3 mg/kg, i.p.) dose-dependently reversed the scopolamine-induced impairment of the maze performance. These results suggest that TMP has therapeutic potential for the treatment of dementia caused by cholinergic dysfunction and/or decrease of cerebral blood flow.
采用大鼠八臂放射状迷宫实验，研究川芎主要成分川芎嗪（TMP）对双侧颈总动脉永久性闭塞（2VO）和东莨菪碱所致空间认知障碍的影响。永久性2VO使未预先训练的大鼠产生严重的学习缺陷。永久性2VO后第3天开始每日腹腔注射TMP（3 - 10 mg/kg）可显著改善学习缺陷。TMP对预先训练的永久性2VO大鼠的记忆保持任务损伤无影响，但倾向于减少这些大鼠因3分钟延迟插入而增加的错误次数。在东莨菪碱模型中，东莨菪碱（0.3 mg/kg，腹腔注射）显著降低初始正确反应并增加错误次数。单次腹腔注射TMP（1 - 3 mg/kg）剂量依赖性地逆转了东莨菪碱所致的迷宫行为损伤。这些结果表明，TMP对治疗由胆碱能功能障碍和/或脑血流量减少引起的痴呆具有治疗潜力。
