Ulm M R, Chalubinski K, Ulm C, Plöckinger B, Deutinger J, Bernaschek G
Department of Obstetrics and Gynaecology, School of Dentistry, University of Vienna, Austria.
Prenat Diagn. 1995 Apr;15(4):368-72. doi: 10.1002/pd.1970150412.
Recently, sonography of the fetal face has gained increasing importance in prenatal diagnosis. It is not yet clear whether sonographic depiction of fetal tooth germs would have an influence on the prenatal diagnosis of ectodermal dysplasia syndromes. During routine malformation screening, horizontal sections of fetal jaws were visualized and examined for tooth germs in 124 pregnant women following sonographic 'facing'. Histological jaw sections of fetuses that had died in utero at various gestational ages were produced in order to examine the degree of correspondence between the sonographic and histological findings. At least four tooth germs were found in the jaws of all fetuses between 19 and 34 gestational weeks (n = 104). Although jaw visualization was possible between 14 and 18 gestational weeks (n = 20), the exact number and location of the tooth germs could not be determined. Assessment of tooth germs may become increasingly important, as aplasia of the tooth germs is one of the principal signs of various hereditary ectodermal diseases.
最近，胎儿面部超声检查在产前诊断中的重要性日益增加。目前尚不清楚超声对胎儿牙胚的描绘是否会对外胚层发育不良综合征的产前诊断产生影响。在常规畸形筛查中，对124名孕妇进行超声“面部检查”后，观察胎儿颌骨的水平切面并检查牙胚。制作了不同孕周在子宫内死亡胎儿的颌骨组织切片，以检查超声检查结果与组织学检查结果的相符程度。在孕19至34周的所有胎儿（n = 104）的颌骨中至少发现了4个牙胚。虽然在孕14至18周（n = 20）时可以观察到颌骨，但无法确定牙胚的确切数量和位置。由于牙胚发育不全是各种遗传性外胚层疾病的主要体征之一，对牙胚的评估可能会变得越来越重要。
