血管紧张素II对非缺氧和缺氧小鼠脑单胺的影响。
Effects of angiotensin II on brain monoamines in nonhypoxic and hypoxic mice.
作者信息
Georgiev V, Stancheva S, Getova D, Alova L, Opitz M
机构信息
Department of Experimental Pharmacology, Bulgarian Academy of Sciences, Sofia.
出版信息
Pharmacol Biochem Behav. 1995 Mar;50(3):457-61. doi: 10.1016/0091-3057(94)00311-6.
The effects of angiotensin II (ATII) administered intracerebroventricularly (ICV, acute) and subcutaneously (SC, acute and chronic) on acute hypoxia (asphyctic and hemic), and on the forebrain concentrations of monoamines dopamine (DA), norepinephrine (NE), and serotonin (5-HT) in male mice were studied. ATII in both routes of administration exerted a decrease of the latency to hypoxia-induced convulsions. ATII slightly reduced the brain levels of DA and NE, and did not change those of 5-HT in hypoxic mice. ATII significantly reduced DA and 5-HT concentrations in nonhypoxic (normoxic) mice. Taken together, the results suggest that ATII-induced increase of susceptibility to hypoxia is accompanied by slight alterations in the brain monoamine metabolism.
研究了脑室内（急性）和皮下（急性和慢性）注射血管紧张素II（ATII）对雄性小鼠急性缺氧（窒息性和缺血性）以及前脑单胺多巴胺（DA）、去甲肾上腺素（NE）和5-羟色胺（5-HT）浓度的影响。两种给药途径的ATII均使缺氧诱导惊厥的潜伏期缩短。ATII使缺氧小鼠的脑内DA和NE水平略有降低，而5-HT水平未发生变化。ATII使非缺氧（常氧）小鼠的DA和5-HT浓度显著降低。综上所述，结果表明ATII诱导的对缺氧易感性增加伴随着脑单胺代谢的轻微改变。
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