Yamashita S, Oishi R, Gomita Y
Department of Hospital Pharmacy, Okayama University Medical School, Japan.
Pharmacol Biochem Behav. 1995 Mar;50(3):477-9. doi: 10.1016/0091-3057(94)00284-p.
The anticonflict activities of buspirone and gepirone were examined in the Vogel's water licking test in rats. Acute treatment with buspirone induced a significant increase in water licking response, but gepirone showed slightly more marked effect than buspirone. The anticonflict activities of these compounds were potentiated by chronic administration. Especially, gepirone exhibited a dramatically remarkable anticonflict effect. These results suggest that gepirone has a great possibility of promising drug for anxiety.
在大鼠的Vogel饮水试验中检测了丁螺环酮和吉哌隆的抗冲突活性。丁螺环酮急性给药可使饮水反应显著增加，但吉哌隆的作用比丁螺环酮稍明显。这些化合物的抗冲突活性通过长期给药得到增强。特别是，吉哌隆表现出显著的抗冲突作用。这些结果表明，吉哌隆很有可能成为治疗焦虑症的有效药物。
