乳腺闪烁造影：锝-99m 甲氧基异丁基异腈俯卧位乳腺成像在乳腺癌诊断中的辅助作用。

Scintimammography: the complementary role of Tc-99m sestamibi prone breast imaging for the diagnosis of breast carcinoma.

作者信息

Khalkhali I, Cutrone J A, Mena I G, Diggles L E, Venegas R J, Vargas H I, Jackson B L, Khalkhali S, Moss J F, Klein S R

机构信息

Department of Radiology, Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance 90502, USA.

出版信息

Radiology. 1995 Aug;196(2):421-6. doi: 10.1148/radiology.196.2.7617855.

DOI:10.1148/radiology.196.2.7617855

PMID:7617855

Abstract

PURPOSE

To evaluate the complementary role of technetium-99m sestamibi scintimammography in improvement of the sensitivity and specificity of mammography in detection of carcinoma of the breast.

MATERIALS AND METHODS

At 5 and 60 minutes after intravenous injection of Tc-99m sestamibi, scintimammograms were obtained in 147 women (age range, 18-73 years; mean age, 47.9 years +/- 10.2 [standard deviation]) with 153 lesions that warranted breast biopsy (102 lesions) or fine-needle aspiration cytologic analysis (51 lesions). There were 113 palpable and 40 nonpalpable lesions. Lesion size on mammograms was 0.8 x 0.6 cm to 15.0 x 11.0 cm (mean, 2.82 cm +/- 1.71 x 2.39 cm +/- 1.56).

RESULTS

Scintimammographic findings were true-positive in 47 biopsy-confirmed carcinomas, true-negative in 91 benign lesions, false-positive in 11 lesions with benign histopathologic findings (fibrocystic disease [n = 8] or fibroadenoma [n = 3]), and false-negative in four lesions of infiltrating ductal carcinoma. The sensitivity of scintimammography was 92.2%; specificity, 89.2%; positive predictive value, 81.0%; and negative predictive value, 95.8%.

CONCLUSION

The authors conclude that scintimammography is a sensitive test that can improve the detection of breast carcinoma.

摘要

目的

评估锝-99m 甲氧基异丁基异腈乳腺闪烁显像在提高乳腺钼靶摄影检测乳腺癌的敏感性和特异性方面的辅助作用。

材料与方法

对147名女性（年龄范围18 - 73岁；平均年龄47.9岁±10.2[标准差]）进行了乳腺闪烁显像，这些女性有153处病变需要进行乳腺活检（102处病变）或细针穿刺细胞学分析（51处病变）。其中有113处可触及病变和40处不可触及病变。乳腺钼靶片上病变大小为0.8×0.6 cm至15.0×11.0 cm（平均，2.82 cm±1.71×2.39 cm±1.56）。

结果

在47例经活检证实的乳腺癌中，乳腺闪烁显像结果为真阳性；在91例良性病变中为真阴性；在11例具有良性组织病理学结果（纤维囊性疾病[n = 8]或纤维腺瘤[n = 3]）的病变中为假阳性；在4例浸润性导管癌病变中为假阴性。乳腺闪烁显像的敏感性为92.2%；特异性为89.2%；阳性预测值为81.0%；阴性预测值为95.8%。