Laya M B, Gallagher J C, Schreiman J S, Larson E B, Watson P, Weinstein L
Department of Medicine, University of Washington, Seattle 98195, USA.
Radiology. 1995 Aug;196(2):433-7. doi: 10.1148/radiology.196.2.7617857.
To measure changes and predictors of change in mammograms obtained in postmenopausal women undergoing continuous combined hormonal replacement therapy (HRT).
Mammograms of 41 postmenopausal women obtained before and 1 year after the initiation of HRT were evaluated blindly according to the quantitative density percentage method and the Wolfe classification system.
Mammographic densities increased compared with baseline values in 73% of subjects (mean increase, 6.7%; 95% confidence interval, 2.5%, 11.0%; P = .003). A shift in Wolfe classification from lower to greater parenchymal density was noted in 24% of subjects (P = .016). Multivariate analysis results indicated that the lower the tissue density percentage before treatment, the greater the increase in density percentage after treatment.
An increase in mammographic density was demonstrated in most subjects undergoing continuous combined HRT and was most pronounced in subjects with a lower baseline density percentage.
测量接受连续联合激素替代疗法（HRT）的绝经后女性乳房X线照片的变化及变化的预测因素。
根据定量密度百分比法和沃尔夫分类系统，对41名绝经后女性在开始HRT前和开始后1年获得的乳房X线照片进行盲法评估。
73%的受试者乳房X线密度较基线值增加（平均增加6.7%；95%置信区间，2.5%，11.0%；P = .003）。24%的受试者沃尔夫分类从较低的实质密度转变为较高的实质密度（P = .016）。多变量分析结果表明，治疗前组织密度百分比越低，治疗后密度百分比增加越大。
大多数接受连续联合HRT的受试者乳房X线密度增加，且在基线密度百分比较低的受试者中最为明显。
