Zarcone V P, Benson K L
Psychiatry Service, Department of Veterans Affairs Medical Center, Palo Alto, California 94304, USA.
Sleep. 1995 May;18(4):266-71. doi: 10.1093/sleep/18.4.266.
Rapid eye movement (REM) sleep middle ear muscle activity (MEMA) was recorded in four diagnostic groups: schizophrenics (n = 18), schizoaffectives (n = 8), depressives (n = 11) and healthy, nonpsychiatric controls (n = 10). Previous work suggested that schizophrenics have higher than normal rates of REM sleep MEMA; this previous study employed the MEMA recording technique of impedance audiometry, which involves a 90-dB stimulus probe tone. The present study, which utilized a silent, pressure-sensitive transducer (i.e. no acoustic stimulus), was undertaken to determine if the stimulus tone might have elicited excess MEMA in the schizophrenics. In this present study, we observed no significant differences in REM sleep MEMA among the four diagnostic groups, suggesting that REM sleep MEMA cannot be used as a biological marker to differentiate clinical disorders. This failure to replicate our previous finding of high MEMA rates in schizophrenics is likely due to sampling error; alternatively, high REM sleep MEMA rates might be elicited in a subgroup of schizophrenics with an acoustic stimulus.
对四个诊断组的快速眼动（REM）睡眠期间的中耳肌肉活动（MEMA）进行了记录，这四个诊断组分别为：精神分裂症患者（n = 18）、精神分裂情感障碍患者（n = 8）、抑郁症患者（n = 11）以及健康的非精神科对照者（n = 10）。先前的研究表明，精神分裂症患者的REM睡眠MEMA发生率高于正常水平；先前的这项研究采用了阻抗测听法的MEMA记录技术，该技术涉及一个90分贝的刺激探测音。本研究使用了一种无声的、对压力敏感的换能器（即无听觉刺激），以确定该刺激音是否可能在精神分裂症患者中引发了过多的MEMA。在本研究中，我们观察到四个诊断组之间在REM睡眠MEMA方面没有显著差异，这表明REM睡眠MEMA不能用作区分临床疾病的生物学标志物。未能重复我们先前在精神分裂症患者中发现的高MEMA发生率这一结果，可能是由于抽样误差；或者，在有听觉刺激的精神分裂症患者亚组中可能会引发高REM睡眠MEMA发生率。
