Rothman N
Occupational Studies Section, NIH/NCI EPN 418, Bethesda, MD 20892, USA.
Toxicol Lett. 1995 May;77(1-3):221-5. doi: 10.1016/0378-4274(95)03298-3.
When using biomarkers to assess genetic susceptibility for cancer risk, the following issues should be recognized: (i) exposure assessment should receive as much attention as marker measurement; (ii) it is critical to study cases with a wide range of exposure patterns; (iii) each approach to evaluating susceptibility has its own potential biases; (iv) it is important to demonstrate the biologic plausibility of gene-exposure interactions detected in epidemiologic studies.
在使用生物标志物评估癌症风险的遗传易感性时，应认识到以下问题：（i）暴露评估应与标志物测量受到同等关注；（ii）研究具有广泛暴露模式的病例至关重要；（iii）每种评估易感性的方法都有其自身潜在的偏差；（iv）证明在流行病学研究中检测到的基因-暴露相互作用的生物学合理性很重要。
