Taioli E, Crofts F, Trachman J, Bayo S, Toniolo P, Garte S J
Nelson Institute of Environmental Medicine, New York University Medical Center, NY 10016, USA.
Toxicol Lett. 1995 May;77(1-3):357-62. doi: 10.1016/0378-4274(95)03318-1.
The cytochrome P450 1A1 (CYP1A1) gene may be of critical importance in determining individual cancer susceptibility to aromatic hydrocarbons such as those in tobacco smoke. We compared the frequencies of CYP1A1 haplotypes, and complete genotypes, taking into account polymorphisms at 3 sites, including an African-specific polymorphism. No concordance was observed in Africans or African-Americans between any of the 3 polymorphisms, (Msp1 restriction fragment length polymorphism (RFLP)--'M', exon 7--'E', new RFLP--'A') in contrast to the concordance seen between the M and E polymorphisms in Caucasians and Asians. We observed an effect of the E polymorphism on enzyme activity and mRNA induction in Asians and Caucasians.
细胞色素P450 1A1（CYP1A1）基因在决定个体对芳香烃（如烟草烟雾中的芳香烃）的癌症易感性方面可能至关重要。我们比较了CYP1A1单倍型和完整基因型的频率，同时考虑了3个位点的多态性，包括一个非洲特异性多态性。在非洲人或非裔美国人中，3种多态性（Msp1限制性片段长度多态性（RFLP）——“M”，外显子7——“E”，新的RFLP——“A”）之间均未观察到一致性，这与白种人和亚洲人中M和E多态性之间的一致性形成对比。我们在亚洲人和白种人中观察到E多态性对酶活性和mRNA诱导的影响。
