Wilkinson S P, Portmann B, Williams R
Gut. 1979 Jan;20(1):33-6. doi: 10.1136/gut.20.1.33.
The clinical course and histological changes in the liver during a presumed adverse reaction to the drug dantrolene sodium are described in four patients. After a typical prodrome one developed a moderately severe hepatitis-like illness. Another also had a prodrome but never became jaundiced. In the other two, abnormal liver function tests were detected on routine screening. In each case liver biopsy showed changes typical of an acute hepatitis, but the severity was unrelated to the clinical presentation. In addition, there were also changes in the portal tracts resembling ascending cholangitis. In each case liver function tests returned to normal after withdrawing treatment with dantrolene.
本文描述了4例患者在使用丹曲林钠药物后可能出现不良反应期间肝脏的临床病程和组织学变化。在典型的前驱症状后，1例患者发展为中度严重的肝炎样疾病。另1例患者也有前驱症状，但从未出现黄疸。另外2例患者在常规筛查中发现肝功能检查异常。在每例患者中，肝活检均显示出急性肝炎的典型变化，但严重程度与临床表现无关。此外，门静脉区域也有类似上行性胆管炎的变化。在每例患者中，停用丹曲林治疗后肝功能检查恢复正常。
