Mouthon L, Deblois P, Sauvaget F, Meyrier A, Callard P, Guillevin L
Service de Médecine interne, Hôpital Avicenne, Bobigny, France.
Am J Nephrol. 1995;15(3):266-9. doi: 10.1159/000168844.
We report the case of man with a history of post-transfusion chronic persistent hepatitis due to hepatitis B virus (HBV), who secondarily developed polyarteritis nodosa (PN) and membranous nephropathy (MN) simultaneously. At that time, liver biopsy yielded the diagnosis of active chronic hepatitis, and serological tests showed a high replication rate of HBV. PN was due to HBV infection, but the etiology of MN was uncertain, as it has never been described in PN, even in its microscopic form. There was no evidence of paraneoplastic syndrome or other causes of MN. Although the renal biopsy did not give any indication of HBV-related glomerulonephritis, the patient was considered to have an association of classic PN and MN, both related to HBV. Treatment combined plasmapheresis and interferon-alpha.
我们报告了一例有输血后慢性持续性乙型肝炎病毒（HBV）感染病史的男性患者，该患者继发同时出现结节性多动脉炎（PN）和膜性肾病（MN）。当时，肝脏活检确诊为活动性慢性肝炎，血清学检查显示HBV复制率高。PN是由HBV感染引起的，但MN的病因尚不确定，因为在PN中从未有过相关描述，即使是其微观形式。没有副肿瘤综合征或其他MN病因的证据。尽管肾活检未提示HBV相关性肾小球肾炎，但该患者被认为患有经典PN和MN，两者均与HBV相关。治疗采用血浆置换和α干扰素联合。
