肾移植与骨质疏松症
Renal transplantation and osteoporosis.
作者信息
Boot A M, Nauta J, Hokken-Koelega A C, Pols H A, de Ridder M A, de Muinck Keizer-Schrama S M
机构信息
Department of Paediatrics, Sophia Children's Hospital, Medical Schools of Erasmus University, Rotterdam, The Netherlands.
出版信息
Arch Dis Child. 1995 Jun;72(6):502-6. doi: 10.1136/adc.72.6.502.
A cross sectional study assessed the bone mineral density (BMD) of 20 young adult patients who received a renal transplantation in childhood. The BMD of the lumbar spine, mainly trabecular bone, and of the total body, mainly cortical bone, were measured and expressed as an SD score. Fourteen patients (70%) had a BMD SD score of the lumbar spine below -1, of whom six patients were below -2. Fifteen patients (75%) had a BMD SD score of the total body below -1, of whom seven patients were below -2, Both trabecular and cortical bone appeared to be involved in the osteopenic process. The cumulative dose of prednisone was inversely correlated to both lumbar spine and total body BMD SD score. In a multiple regression analysis the cumulative dose of prednisone appeared to be the only factor with a significant effect on BMD SD score. Most young adult patients who had received a renal transplantation in childhood had moderate to severe osteopenia. Corticosteroid treatment played a major part in the development of osteopenia in these patients.
一项横断面研究评估了20例童年时期接受肾移植的年轻成年患者的骨矿物质密度（BMD）。测量了主要为小梁骨的腰椎和主要为皮质骨的全身的BMD，并将其表示为标准差分数。14例患者（70%）腰椎的BMD标准差分数低于-1，其中6例患者低于-2。15例患者（75%）全身的BMD标准差分数低于-1，其中7例患者低于-2。小梁骨和皮质骨似乎都参与了骨质减少的过程。泼尼松的累积剂量与腰椎和全身BMD标准差分数呈负相关。在多元回归分析中，泼尼松的累积剂量似乎是对BMD标准差分数有显著影响的唯一因素。大多数童年时期接受肾移植的年轻成年患者有中度至重度骨质减少。皮质类固醇治疗在这些患者骨质减少的发生中起主要作用。
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