Chrobak J J, Hanin I, Lorens S A, Napier T C
Department of Pharmacology and Experimental Therapeutics, Stritch School of Medicine, Loyola University of Chicago, USA.
Behav Neurosci. 1995 Apr;109(2):241-5. doi: 10.1037//0735-7044.109.2.241.
A within-subject design was used to examine delayed-non-match-to-sample radial arm maze performance in aging (6-18 months) male Sprague-Dawley rats. A decrease in correct choices and an increase in retroactive errors were observed at all retention intervals at 18 months of age compared with performance at 6 or 12 months. No age by retention interval interaction was observed. Neither age nor increasing retention interval influenced proactive errors during the retention test. The observation of an age- and delay-dependent increase in retroactive errors, but not proactive errors, suggests that the deficit relates to a memory dysfunction as opposed to a generalized performance deficit.
