• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

新生期性腺激素环境的变化会阻止行为保留，并改变雄性和雌性大鼠早期额叶皮质损伤后的皮质形态发生。

Changes in the neonatal gonadal hormonal environment prevent behavioral sparing and alter cortical morphogenesis after early frontal cortex lesions in male and female rats.

作者信息

Kolb B, Stewart J

机构信息

Department of Psychology, University of Lethbridge, Alberta, Canada.

出版信息

Behav Neurosci. 1995 Apr;109(2):285-94. doi: 10.1037//0735-7044.109.2.285.

DOI:10.1037//0735-7044.109.2.285
PMID:7619318
Abstract

The effects of perinatal exposure to testicular hormones were studied in male and female rats given medial prefrontal lesions (PFC) on Postnatal Day 7. Hormonally intact rats with PFC lesions showed recovery of performance of the Morris water task but no recovery on a forelimb reaching task. Recovery was abolished in both males gonadectomized at birth and in females given testosterone at birth. Male rats with PFC lesions showed an increase in pyramidal cell spine density. This was blocked in gonadectomized animals. In contrast, female rats with PFC lesions showed an increase in dendritic arbor. This was reduced by perinatal testosterone. Interference with the gonadal hormonal environment reduced the brain's ability to compensate for the effects of early cortical lesions.

摘要

在出生后第7天对雄性和雌性大鼠进行内侧前额叶损伤（PFC），研究围产期暴露于睾丸激素的影响。具有PFC损伤的激素完整大鼠在莫里斯水迷宫任务中的表现有所恢复，但在前肢够物任务中没有恢复。出生时去势的雄性大鼠和出生时给予睾酮的雌性大鼠的恢复均被消除。具有PFC损伤的雄性大鼠锥体细胞棘密度增加。这在去势动物中被阻断。相比之下，具有PFC损伤的雌性大鼠树突分支增加。围产期睾酮使其减少。对性腺激素环境的干扰降低了大脑补偿早期皮质损伤影响的能力。

相似文献

1
Changes in the neonatal gonadal hormonal environment prevent behavioral sparing and alter cortical morphogenesis after early frontal cortex lesions in male and female rats.新生期性腺激素环境的变化会阻止行为保留，并改变雄性和雌性大鼠早期额叶皮质损伤后的皮质形态发生。
Behav Neurosci. 1995 Apr;109(2):285-94. doi: 10.1037//0735-7044.109.2.285.
2
Sex differences in the effects of frontal cortex injury: role of differential hormonal experience in early development.额叶皮质损伤影响中的性别差异：早期发育中不同激素经历的作用。
Behav Neurosci. 1998 Feb;112(1):141-53. doi: 10.1037//0735-7044.112.1.141.
3
Sparing of function after neonatal frontal lesions correlates with increased cortical dendritic branching: a possible mechanism for the Kennard effect.新生儿额叶病变后功能保留与皮质树突分支增加相关：肯纳德效应的一种可能机制。
Behav Brain Res. 1991 Apr 18;43(1):51-6. doi: 10.1016/s0166-4328(05)80051-8.
4
Therapeutic effects of complex rearing or bFGF after perinatal frontal lesions.围产期额叶损伤后复合饲养或碱性成纤维细胞生长因子的治疗效果。
Dev Psychobiol. 2008 Mar;50(2):134-46. doi: 10.1002/dev.20253.
5
Possible anatomical basis of recovery of function after neonatal frontal lesions in rats.
Behav Neurosci. 1993 Oct;107(5):799-811. doi: 10.1037//0735-7044.107.5.799.
6
Contrasting effects of motor and visual spatial learning tasks on dendritic arborization and spine density in rats.运动和视觉空间学习任务对大鼠树突分支和棘密度的对比效应。
Neurobiol Learn Mem. 2008 Sep;90(2):295-300. doi: 10.1016/j.nlm.2008.04.012. Epub 2008 Jun 10.
7
Manipulation of gonadal hormones in neonatal rats alters the morphological response of cortical neurons to brain injury in adulthood.对新生大鼠性腺激素进行调控会改变成年期皮质神经元对脑损伤的形态学反应。
Behav Neurosci. 2003 Apr;117(2):257-62. doi: 10.1037/0735-7044.117.2.257.
8
Recovery from early cortical damage in rats, VIII. Earlier may be worse: behavioural dysfunction and abnormal cerebral morphogenesis following perinatal frontal cortical lesions in the rat.大鼠早期皮质损伤的恢复，VIII. 更早可能更糟：大鼠围产期额叶皮质损伤后的行为功能障碍和异常脑形态发生
Neuropharmacology. 2000 Mar 3;39(5):756-64. doi: 10.1016/s0028-3908(99)00260-9.
9
Functional recovery and dendritic hypertrophy after posterior and complete cingulate lesions on postnatal day 10.
Dev Psychobiol. 2002 Mar;40(2):138-46.
10
Does dendritic growth underly recovery from neonatal occipital lesions in rats.树突状生长是否是大鼠新生儿枕叶损伤后恢复的基础。
Behav Brain Res. 1996 May;77(1-2):125-33. doi: 10.1016/0166-4328(95)00208-1.

引用本文的文献

1
Sensitive Periods for Recovery from Early Brain Injury.早期脑损伤康复的敏感期。
Curr Top Behav Neurosci. 2022;53:189-212. doi: 10.1007/7854_2021_296.
2
Longitudinal Neuroimaging in Pediatric Traumatic Brain Injury: Current State and Consideration of Factors That Influence Recovery.小儿创伤性脑损伤的纵向神经影像学：现状及影响恢复因素的考量
Front Neurol. 2019 Dec 13;10:1296. doi: 10.3389/fneur.2019.01296. eCollection 2019.
3
Sex differences in hippocampal cognition and neurogenesis.海马体认知和神经发生中的性别差异。
Neuropsychopharmacology. 2019 Jan;44(1):200-213. doi: 10.1038/s41386-018-0208-4. Epub 2018 Sep 7.
4
On the effects of testosterone on brain behavioral functions.论睾酮对大脑行为功能的影响。
Front Neurosci. 2015 Feb 17;9:12. doi: 10.3389/fnins.2015.00012. eCollection 2015.
5
Administration of dehydroepiandrosterone (DHEA) increases serum levels of androgens and estrogens but does not enhance short-term memory in post-menopausal women.给予脱氢表雄酮（DHEA）会增加绝经后妇女的血清雄激素和雌激素水平，但不能增强短期记忆。
Brain Res. 2012 Nov 5;1483:54-62. doi: 10.1016/j.brainres.2012.09.015. Epub 2012 Sep 14.
6
Administration of dehydroepiandrosterone (DHEA) enhances visual-spatial performance in postmenopausal women.给予脱氢表雄酮（DHEA）可增强绝经后女性的视觉空间能力。
Behav Neurosci. 2011 Oct;125(5):742-52. doi: 10.1037/a0025151.
7
Gender influences cerebral oxygenation after red blood cell transfusion in patients with severe traumatic brain injury.性别会影响严重创伤性脑损伤患者输注红细胞后的脑氧合。
Neurocrit Care. 2011 Feb;14(1):18-23. doi: 10.1007/s12028-010-9441-3.
8
Amphetamine or cocaine limits the ability of later experience to promote structural plasticity in the neocortex and nucleus accumbens.安非他命或可卡因会限制后续经历促进新皮层和伏隔核结构可塑性的能力。
Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10523-8. doi: 10.1073/pnas.1834271100. Epub 2003 Aug 25.