Ballarè M, Quaglia V, Di Natale C, Zaccala G, Catania E, Fortina G, Monteverde A
Divisione di Medicina Generale II, Ospedale Maggiore di Novara.
Ann Ital Med Int. 1995 Apr-Jun;10(2):98-101.
The frequent association of chronic hepatitic C virus (HCV) infection and type II mixed cryoglobulinemia is considered to be one of the possible signs of interaction between the virus and the immune system. This could also be the case for the appearance of anti-GOR antibodies in serum, as they react with both viral and host antigens. We studied a group of patients with chronic hepatitis C infection and a group with type II mixed cryoglobulinemia associated with HCV infection to ascertain if anti-GOR or other non-organ specific autoantibodies were present in the serum. We found no significant difference between the two groups in presence, prevalence or titer of anti-GOR or other autoantibodies. Moreover, the expression of anti-GOR does not seem to influence the severity of liver damage. Our data support the hypothesis that anti-GOR antibodies are a simple expression of molecular mimicry between viral and human epitopes.
慢性丙型肝炎病毒（HCV）感染与II型混合性冷球蛋白血症的频繁关联被认为是病毒与免疫系统之间相互作用的可能迹象之一。血清中抗GOR抗体的出现也可能如此，因为它们能与病毒抗原和宿主抗原发生反应。我们研究了一组慢性丙型肝炎感染患者以及一组与HCV感染相关的II型混合性冷球蛋白血症患者，以确定血清中是否存在抗GOR或其他非器官特异性自身抗体。我们发现两组在抗GOR或其他自身抗体的存在、流行率或滴度方面没有显著差异。此外，抗GOR的表达似乎并不影响肝损伤的严重程度。我们的数据支持这样的假设，即抗GOR抗体是病毒表位与人类表位之间分子模拟的一种简单表现。
