法属圭亚那三个美洲印第安人群体中的免疫球蛋白同种异型（GM和KM）

Immunoglobulin allotypes (GM and KM) in three Amerindian populations of French Guiana.

作者信息

Dugoujon J M, Maurieres P, Grenand P, Bois E

机构信息

Centre d'Immunopathologie et de Génétique (CIGH-CNRS), Hôpital Purpan, Toulouse, France.

出版信息

Gene Geogr. 1994 Apr;8(1):13-24.

PMID:7619772

Abstract

We have studied 506 Amerindians from three French Guiana groups: 194 Wayampi, living in Trois-Sauts, and 100 living in the Camopi area; 47 Emerillon also living in the Camopi area and 165 Wayana living on the Litani and Maroni rivers. All samples were tested for G1M (1,2,3,17), G3M (5,6,10,11,13,14,15,16,21,24,28) and KM(1) by the classical method of hemaglutination inhibition. The phenotype and haplotype distributions are presented and have been subjected to factorial analysis of correspondence. Two common GM haplotypes are GM1,17:21,28 and GM1,2,17;21,28 but with an important variation in frequency. A rare haplotype, GM1,17;21R,28, probably the result of a genetic anomaly, is frequent in the Emerillon (17%). These populations show no evidence of Negroid or Caucasian admixtures.

摘要

我们研究了来自法属圭亚那三个群体的506名美洲印第安人：194名瓦扬皮人，生活在特鲁瓦索；100名生活在卡莫皮地区；47名埃梅里永人也生活在卡莫皮地区；165名瓦亚纳人生活在利塔尼河和马罗尼河沿岸。所有样本均通过经典的血凝抑制方法检测了G1M(1,2,3,17)、G3M(5,6,10,11,13,14,15,16,21,24,28)和KM(1)。呈现了表型和单倍型分布，并对其进行了对应因子分析。两种常见的GM单倍型是GM1,17:21,28和GM1,2,17;21,28，但频率存在重要差异。一种罕见的单倍型GM1,17;21R,28，可能是基因异常的结果，在埃梅里永人中很常见(17%)。这些人群没有显示出与黑人或白种人混合的迹象。