[智利城市人口样本中的免疫球蛋白重链和轻链同种异型]

[Gm and Km allotypes in a Chilean urban population sample].

作者信息

Arcos-Burgos M, Valenzuela C Y, Herrera P J, Pandey J P

机构信息

Departamento de Biología Celular y Genética, Facultad de Medicina, Universidad de Chile, Santiago, Chile.

出版信息

Rev Med Chil. 1997 Feb;125(2):161-4.

PMID:9430935

Abstract

BACKGROUND

The knowledge of the genic structure of a population is of great importance for evolutive studies.

AIM

To estimate in a Chilean population sample from the low-middle and low socioeconomic strata of Santiago, haplotypes and allele frequencies for Gm and Km loci.

SUBJECTS AND METHODS

The sample included 460 controls of a case-control study of typhoid fever.

RESULTS

The G1m-G2m-G3m most frequent haplotypes were: za;..;g or 1,17;(-);21 = 0.4493;fn;b or 3;23;5,13 = 0.2522; f-,..;b or 3;(-);5,13 = 0.1389; zax;..;g or 1,2,17;(-);21 = 0.0685; za;..;b or 1,17;(-);5,13 = 0.0454; za;n;g or 1,17;23;21 = 0.0207; f;..;g or 3;(-);21 = 0.0129. The frequencies of Km alleles were 0.2391 and 0.7609 for Km1 and Km3 respectively.

CONCLUSIONS

These frequencies are within those found in Amerindian and Caucasian populations as expected from the origin of the Chilean population. Gm haplotypes did not differ from Hardy-Weinberg equilibrium, while a significant lack of homozygous Km1/km1 was found in Km.

摘要

背景

群体基因结构的知识对于进化研究非常重要。

目的

在来自圣地亚哥中低和低社会经济阶层的智利人群样本中，估计Gm和Km基因座的单倍型和等位基因频率。

对象与方法

样本包括伤寒热病例对照研究中的460名对照。

结果

G1m - G2m - G3m最常见的单倍型为：za;..;g或1,17;(-);21 = 0.4493；fn;b或3;23;5,13 = 0.2522；f -,..;b或3;(-);5,13 = 0.1389；zax;..;g或1,2,17;(-);21 = 0.0685；za;..;b或1,17;(-);5,13 = 0.0454；za;n;g或1,17;23;21 = 0.020；f;..;g或3;(-);21 = 0.0129。Km1和Km3的Km等位基因频率分别为0.2391和0.7609。