捷克斯洛伐克人群样本以及两组意大利人群样本中的线粒体DNA多态性
MtDNA polymorphisms in a sample of Czechoslovaks and in two groups of Italians.
作者信息
Brega A, Mura G, Caccio S, Semino O, Brdicka R, Santachiara-Benerecetti A S
机构信息
Dipartimento di Biologia e Genetica per le Scienze Mediche, Università di Milano, Italy.
出版信息
Gene Geogr. 1994 Apr;8(1):45-54.
Mitochondrial DNA (mtDNA) variation was investigated in a group of 185 unrelated individuals (64 Czechoslovaks, 99 Northern and 28 Central Italians) using total blood DNA and the six restriction enzymes HpaI, BamHI, HaeII, MspI, AvaII and HincII. Among the 25 patterns (morphs) found, two morphs for HaeII, one for MspI and one for AvaII were new and each was represented by a single individual from Northern Italy. They account for four of the five new types encountered in this survey, being the fifth type characterized by the presence of the very rare morph HaeII-13. The populations analysed confirm the Caucasoid characteristics of certain polymorphisms. A review of the European data available so far is reported.
利用全血DNA以及六种限制性内切酶HpaI、BamHI、HaeII、MspI、AvaII和HincII，对一组185名无亲缘关系的个体（64名捷克人、99名意大利北部人以及28名意大利中部人）的线粒体DNA（mtDNA）变异情况进行了研究。在所发现的25种模式（形态）中，HaeII的两种形态、MspI的一种形态以及AvaII的一种形态是新发现的，每种形态均由一名来自意大利北部的个体所代表。它们占本次调查中所遇到的五种新类型中的四种，第五种类型的特征是存在极为罕见的HaeII - 13形态。所分析的人群证实了某些多态性的高加索人种特征。报告了对目前欧洲现有数据的综述。
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