Muñoz Ruiz A I, Calvo Elipe A, Llorente Herrero E, Guerrero Vega E, Pato Alonso S, Rodríguez Dorrego R, Gilsanz Fernández C
Servicio de Medicina Interna I, Hospital General Gregorio Marañón, Madrid.
An Med Interna. 1995 Apr;12(4):189-91.
Carcinoid tumour of the thymus is a rare condition, with less than a hundred cases reported in the literature. Diagnosis is complex as they are usually asymptomatic. We describe a case of a severe Cushing syndrome developed in a 51-year-old man. The diagnosis of a thymic carcinoid was established. Three years ago, the patient was treated by surgical resection of an anterior mediastinal mass. A massive tumour dissemination was detected by MIBG and CT image techniques. Both techniques are currently considered useful for this kind of diagnosis. ACTH secretion was detected immunohistochemically. Although the treatment with SMS-201-995 octreotide was effective in controlling the clinical symptoms, the patient died three months later with extensive metastases. The carcinoid tumours of the thymus associated to Cushing syndrome are aggressive tumours and usually produce local and distant metastases.
胸腺类癌是一种罕见疾病，文献报道的病例不足100例。由于其通常无症状，诊断较为复杂。我们描述了一例51岁男性发生的严重库欣综合征病例。确诊为胸腺类癌。三年前，该患者接受了前纵隔肿物的手术切除。通过间碘苄胍（MIBG）和CT影像技术检测到大量肿瘤播散。目前认为这两种技术对此类诊断均有用。免疫组化检测到促肾上腺皮质激素（ACTH）分泌。尽管使用SMS-201-995奥曲肽治疗能有效控制临床症状，但患者三个月后死于广泛转移。与库欣综合征相关的胸腺类癌是侵袭性肿瘤，通常会发生局部和远处转移。
