Shurtleff D B, Lemire R J
University of Washington, Children's Hospital and Medical Center, Seattle, USA.
Neurosurg Clin N Am. 1995 Apr;6(2):183-93.
The caudal neural tube closes late in the first month after fertilization and failure of it results in myelomeningocele. Epidemiologic studies have shown differences in prevalence at birth based on ethnic-racial backgrounds and geography. Etiologic factors include the drug valproic acid or carbamazepine. Periconceptional folic acid supplementation appears to decrease the prevalence of neural tube defects. Numerous modalities allow for prenatal diagnosis of myelomeningocele. A cesarean section, before rupture of amniotic membranes and onset of labor, decreases the degree of paralysis.
尾侧神经管在受精后第一个月末期闭合，其闭合失败会导致脊髓脊膜膨出。流行病学研究表明，基于种族背景和地理位置，出生时的患病率存在差异。病因包括丙戊酸或卡马西平药物。孕前补充叶酸似乎可降低神经管缺陷的患病率。多种方法可用于脊髓脊膜膨出的产前诊断。在胎膜破裂和临产之前进行剖宫产可减轻瘫痪程度。
