Yamada S, Iacono R P, Andrade T, Mandybur G, Yamada B S
Division of Neurosurgery, Loma Linda University Medical Center, California, USA.
Neurosurg Clin N Am. 1995 Apr;6(2):311-23.
Tethered cord syndrome, manifested by motor and sensory dysfunction and incontinence, is caused by excessive tension in the lumbosacral cord. The underlying mechanism is related to impairment of oxidative metabolism in this region. This theory is derived from redox changes of cytochrome a, a3, and supported by spinal cord blood flow, evoked potential, and histological studies. The well-known finding of elongated spinal cord attached to the tight filum or a tumor is not always demonstrated in imaging studies, and understanding of pathophysiology allows physicians to correctly diagnose and treat patients with tethered cord syndrome.
脊髓拴系综合征表现为运动和感觉功能障碍及大小便失禁，由腰骶部脊髓张力过大所致。其潜在机制与该区域氧化代谢受损有关。这一理论源于细胞色素a、a3的氧化还原变化，并得到脊髓血流、诱发电位及组织学研究的支持。影像学检查并不总能显示出脊髓附着于紧张的终丝或肿瘤导致脊髓拉长这一众所周知的表现，而对病理生理学的理解有助于医生正确诊断和治疗脊髓拴系综合征患者。
