Kashitani N, Kimoto S, Tsunoda M, Ito T, Tsuji T, Ono A, Hiraki Y
Department of Radiology, Okayama University, Medical School, Japan.
Abdom Imaging. 1995 May-Jun;20(3):197-200. doi: 10.1007/BF00200392.
In patients with diffuse liver disease, the portal flow dynamics change markedly in accordance with disease progression and would provide a useful index of progression of stage.
Portal blood flow (PBF) was measured by phase contrast magnetic resonance imaging (MRI) in 21 patients with diffuse liver disease and 20 healthy volunteers. The MRI method was validated by a flow phantom study. The mean PBF could be measured in 6.8 min without breath-holding.
Doppler ultrasound measurements of PBF volume were obtained reproducibly in all the healthy volunteers and were shown to correlate with the MRI values (Doppler: 12.5 +/- 3.2 cm3/s, MRI: 12.0 +/- 3.3 cm3/s; mean +/- SD). The PBF volume of patients with chronic hepatitis showed no significant difference from that of the healthy volunteers. In patients with liver cirrhosis, the PBF volume ranged from 5.01 to 32.3 cm3/s. A significant increase in PBF volume was caused in one patient by massive intrahepatic shunting and a significant decrease was caused in two patients by massive extrahepatic shunting.
The measurement of PBF by phase contrast MRI is clinically useful in predicting intrahepatic or extrahepatic shunting in patients with liver cirrhosis, and may be of value in detecting the progression of stage in diffuse liver diseases.
在弥漫性肝病患者中，门静脉血流动力学随疾病进展而显著变化，可作为疾病分期进展的有用指标。
采用相位对比磁共振成像（MRI）对21例弥漫性肝病患者和20名健康志愿者进行门静脉血流（PBF）测量。通过血流模型研究验证了MRI方法。无需屏气即可在6.8分钟内测量平均PBF。
所有健康志愿者均能重复获得PBF体积的多普勒超声测量值，且与MRI值相关（多普勒：12.5±3.2 cm³/s，MRI：12.0±3.3 cm³/s；平均值±标准差）。慢性肝炎患者的PBF体积与健康志愿者无显著差异。肝硬化患者的PBF体积范围为5.01至32.3 cm³/s。1例患者因大量肝内分流导致PBF体积显著增加，2例患者因大量肝外分流导致PBF体积显著减少。
通过相位对比MRI测量PBF对预测肝硬化患者的肝内或肝外分流具有临床实用性，可能对检测弥漫性肝病的分期进展有价值。
