甲状旁腺激素对培养的兔肋软骨细胞中鸟氨酸脱羧酶的诱导作用。
Induction by parathyroid hormone of ornithine decarboxylase in rabbit costal chondrocytes in culture.
作者信息
Takigawa M, Watanabe R, Ishida H, Asada A, Suzuki F
出版信息
J Biochem. 1979 Jan;85(1):311-4. doi: 10.1093/oxfordjournals.jbchem.a132326.
The activity of ornithine decarboxylase (ODC) in rabbit costal chondrocytes in culture markedly increased after addition of parathyroid hormone (PTH), reaching a maximum 4 to 5 h after PTH addition. The effect of PTH was dose-dependent both in the presence and absence of fetal calf serum. Addition of cycloheximide or actinomycin D prevented the induction of ODC by PTH. Calcitonin, 1,25-dihydroxyvitamin D3, and vitamin A had no stimulatory effect on the activity of ODC, and did not inhibit the induction of ODC by PTH, when added with PTH.
在培养的兔肋软骨细胞中，添加甲状旁腺激素（PTH）后，鸟氨酸脱羧酶（ODC）的活性显著增加，在添加PTH后4至5小时达到最大值。无论有无胎牛血清，PTH的作用均呈剂量依赖性。添加放线菌酮或放线菌素D可阻止PTH对ODC的诱导。降钙素、1,25 - 二羟维生素D3和维生素A对ODC的活性没有刺激作用，并且在与PTH一起添加时，不抑制PTH对ODC的诱导。
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