Niu C H, Black S
J Biol Chem. 1979 Jan 25;254(2):265-7.
Proton and 13C nuclear magnetic resonance measurements indicate that uracil derivatives dissolved in chloroform bind to glycine and phenylalanine tripeptide derivatives through pairs of hydrogen bonds. The N(3)--H and C(4)=0 groups of the uracil ring appear to interact with the C=0 and N--H groups, respectively, of individual amino acid residues, suggesting a fundamental complementarity between uracil and the peptide backbone. The binding occurs in the same concentration range as the hydrogen bonding between derivatives of adenine and uracil under comparable conditions.
质子和13C核磁共振测量表明，溶解在氯仿中的尿嘧啶衍生物通过氢键对与甘氨酸和苯丙氨酸三肽衍生物结合。尿嘧啶环的N(3)-H和C(4)=O基团似乎分别与单个氨基酸残基的C=O和N-H基团相互作用，这表明尿嘧啶与肽主链之间存在基本的互补性。在可比条件下，这种结合发生的浓度范围与腺嘌呤和尿嘧啶衍生物之间的氢键结合相同。
