HLA associated cytotoxic antibody production in dialyzed chronic uraemic patients.

We studied the level of the cytotoxic anti-HLA antibodies (CTA) in 90 hemodialyzed chronic uraemic patients who were on waiting list of transplantation. An association between alleles of HLA A1, B8, DR3 haplotype and the level of CTA was studied. The ratio of the reduced CTA producing subjects was significantly higher in the HLA B8 and DR3 carriers. We could observe the highest ratio in the joint appearance of these alleles. In the presence of HLA A1 allele the ratio was decreased beside B8 or DR3 even as joined attendance of these alleles. Our data suggest a different role of these linked antigens in the regulation of cytotoxic antibody production.