Kovanecz I, Petri I, Kaiser G
Blood Transfusion Center, Albert Szentgyörgyi University, Medical School, Szeged, Hungary.
Acta Microbiol Immunol Hung. 1995;42(1):81-4.
We studied the level of the cytotoxic anti-HLA antibodies (CTA) in 90 hemodialyzed chronic uraemic patients who were on waiting list of transplantation. An association between alleles of HLA A1, B8, DR3 haplotype and the level of CTA was studied. The ratio of the reduced CTA producing subjects was significantly higher in the HLA B8 and DR3 carriers. We could observe the highest ratio in the joint appearance of these alleles. In the presence of HLA A1 allele the ratio was decreased beside B8 or DR3 even as joined attendance of these alleles. Our data suggest a different role of these linked antigens in the regulation of cytotoxic antibody production.
我们研究了90名处于移植等待名单上的慢性尿毒症血液透析患者体内细胞毒性抗HLA抗体（CTA）的水平。研究了HLA A1、B8、DR3单倍型等位基因与CTA水平之间的关联。在HLA B8和DR3携带者中，产生CTA减少的受试者比例显著更高。在这些等位基因共同出现时，我们观察到比例最高。在存在HLA A1等位基因的情况下，即使这些等位基因同时出现，在B8或DR3旁边该比例也会降低。我们的数据表明这些连锁抗原在细胞毒性抗体产生的调节中具有不同作用。
