Kourounakis P N, Tani E
Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, Greece.
Res Commun Mol Pathol Pharmacol. 1995 Apr;88(1):119-22.
beta-Glucuronidase cleaves beta-glucuronides of drugs, steroids, as well as macromolecular compounds containing glucuronic acid bound with a beta-glycoside bond. Therefore, the study of induction of this enzyme by known microsomal enzyme inducers is of obvious interest. The effect of phenobarbital, spironolactone and pregnenolone-16 alpha-carbonitrle on the rat liver beta-glucuronidase was studied. These compounds augmented the activity of this enzyme, in the above increasing order. These results are discussed in view of the influence on pharmacokinetics of many drugs. Furthermore, they may lead to new therapeutic approaches for certain diseases.
β-葡萄糖醛酸酶可裂解药物、类固醇的β-葡萄糖醛酸苷，以及含有通过β-糖苷键结合的葡萄糖醛酸的大分子化合物。因此，研究已知的微粒体酶诱导剂对该酶的诱导作用具有明显的意义。研究了苯巴比妥、螺内酯和孕烯醇酮-16α-腈对大鼠肝脏β-葡萄糖醛酸酶的影响。这些化合物以上述递增顺序增强了该酶的活性。鉴于对许多药物药代动力学的影响，对这些结果进行了讨论。此外，它们可能会为某些疾病带来新的治疗方法。
